By Medically reviewed by Hello Doktor Medical Panel


What is Progyluton® (Estradiol Valerate, Norgestrel) used for?

Progyluton® is commonly used for regulation the menstrual cycle when abnormal uterine bleeding occurs. Because there are fewer side effects with this medication, doctors usually prescribe Progyluton® for young girls and older women with menstrual irregularities.

How should I take Progyluton® (Estradiol Valerate, Norgestrel)?

  • Swallow the tablet whole with water.
  • It may be taken with or without food.

How do I store Progyluton® (Estradiol Valerate, Norgestrel)?

Progyluton® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Progyluton® in the bathroom or the freezer. There may be different brands of Progyluton® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Progyluton® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Progyluton® (Estradiol Valerate, Norgestrel)?

Avoid the use of Progyluton® if you:

  • Are pregnant or breastfeeding.
  • Have undiagnosed vaginal bleeding.
  • Have a suspected or confirmed breast cancer.
  • Have a known or suspected precancerous or cancerous condition that is related to sex steroids.
  • Have liver tumors or a history of liver tumors, either benign or malignant.
  • Have severe liver disease.
  • Have a history of clots, stroke, or heart attack.
  • Have high levels of triglycerides.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category X, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


Side effects

What side effects can occur from Progyluton® (Estradiol Valerate, Norgestrel)?

These side effects could occur when using Progyluton®, such as:

  • Lower stomach pain
  • Delayed menstruation
  • Sudden bleeding/ spotting
  • Breast tenderness
  • Acne and pimples
  • Nausea
  • Water retention
  • Weight gain
  • Mood swings

All these symptoms are temporary and disappear overtime with regular use of these tablets.

However, in some cases this drug can cause serious implications. Consult your doctor immediately if you are facing any of the following issues after the use of this medicine:

  • Uterine hemorrhage
  • Infections in uterus
  • Unusual tiredness
  • Vomiting with weakness and nausea
  • Excessive vaginal bleeding
  • Gasrto-intestinal cramps
  • Severe headache and anxiety



What drugs may interact with Progyluton® (Estradiol Valerate, Norgestrel)?

Progyluton® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Progyluton® (Estradiol Valerate, Norgestrel)?

Progyluton® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Progyluton® (Estradiol Valerate, Norgestrel)?

Progyluton® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.



The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Progyluton® (Estradiol Valerate, Norgestrel).

What is the dose of Progyluton® (Estradiol Valerate, Norgestrel) for an adult?

The dosage for these tablets begin with 1 tablet from the first day of menstrual cycle. Then one tablet each day for 20 days, followed by 7 days without taking the tablet.

If you want to continue the course of this medicine again, start with the new strip from 8th day since you took the tablet last.

What is the dose of Progyluton® (Estradiol Valerate, Norgestrel) for a child?

This medicine should not be given to children and infants. Keep this tablet away from the reach of children. If a child accidentally takes this tablet, rush him immediately to your doctor.

How is Progyluton® (Estradiol Valerate, Norgestrel) available?

Progyluton® is available in the following dosage forms and strengths:

  • 11 White Tablet; Oral; Estradiol Valerate 2 mg
  • 10 Brown Tablet; Oral; Estradiol Valerate 2 mg; Norgestrel 0.5 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Progyluton®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: December 25, 2016 | Last Modified: December 19, 2019

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