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Unasyn® is a penicillin antibiotic. It works by blocking the bacteria’s cell wall growth, which kills the bacteria.
It is commonly used for treating infections caused by certain bacteria.
Unasyn® is given as an injection at your doctor’s office, hospital, or clinic.
Unasyn® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Unasyn® in the bathroom or the freezer. There may be different brands of Unasyn® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.
You should not flush Unasyn® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.
Before using this drug, tell your doctor if:
There are no adequate studies in women for determining risk when using Unasyn® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Unasyn®. Unasyn® is pregnancy risk category B, according to the US Food and Drug Administration (FDA).
FDA pregnancy risk category reference below:
Check with your doctor if any of these most common side effects persist or become bothersome:
Seek medical attention right away if any of these severe side effects occur:
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
Unasyn® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Products that may interact with this drug, such as:
Unasyn® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
Unasyn® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
Especially if any of the followings apply to you:
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Unasyn® (ampicillin/sulbactam).
Gynecologic Infections
The recommended dose is 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day.
Intra-Abdominal Infections
The recommended dose is 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day.
Skin & Skin Structure Infections
The recommended dose is 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day.
Orbital Cellulitis
The recommended dose is 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr.
Pelvic Inflammatory Disease
The recommended dose is 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr.
Pneumonia
Aspiration or community acquired: The recommended dose is 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 5 or more days.
Hospital acquired: The recommended dose is 3 g IV q6hr for 5 or more days.
Pyelonephritis:
The recommended dose is 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 14 days
Severe infection requiring hospitalization
The recommended dose is 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 5-7 days.
Enterococcus infection resistant to penicillin/susceptible to aminoglycosides:
The recommended dose is 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 6 weeks if not aminoglycoside resistant; >6 weeks if aminoglycoside resistant.
HACEK infection:
The recommended dose is 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 4 weeks.
Skin Infections
>1 year (<40 kg): The recommended dose is 200 mg/kg/day IV divided q6hr; not to exceed 14 days of therapy.
>1 year (>40 kg): The recommended dose is 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) q6hr; not to exceed 12 g/day.
Epiglottitis
Children and adolescents: The recommended dose is 100-200 mg ampicillin/kg/day IV divided q6hr.
Mild/Moderate Infection
Meningitis/Severe Infections
Peritonsillar and Retropharyngeal Abscess
Unasyn® is available in the following dosage forms and strengths:
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
If you miss a dose of Unasyn®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
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