By Medically reviewed by Hello Doktor Medical Panel


What is Erylik® (Erythromycin, Tretinoin) used for?

Erylik® is commonly used for slowing the growth of bacteria on the skin, which causes acne.

How should I take Erylik® (Erythromycin, Tretinoin)?

  • Wash affected areas with soap and water. Rinse well and pat dry before applying for the medicine.
  • Cover the affected and surrounding area with a thin film of medicine. Spread the medicine lightly over the affected areas rather than rubbing it in. Allow the medicine to dry.
  • Wash your hands immediately after applying the gel.

How do I store Erylik® (Erythromycin, Tretinoin)?

Erylik® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Erylik® in the bathroom or the freezer. There may be different brands of Erylik® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Erylik® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Erylik® (Erythromycin, Tretinoin) ?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any ingredients of Erylik® or other medication.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Erylik® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Erylik®. Erylik® is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk;
  • B=No risk in some studies;
  • C=There may be some risk;
  • D=Positive evidence of risk;
  • X=Contraindicated;
  • N=Unknown.

Side effects

What side effects can occur from Erylik® (Erythromycin, Tretinoin)?

Erylik® may cause these side effects:

  • Peeling;
  • Redness;
  • Dry or scaly skin;
  • Irritation;
  • Itching;
  • Stinging or burning feeling.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Erylik® (Erythromycin, Tretinoin)?

Erylik® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Taking Erylik® with these medications may cause interactions:

  • Efavirenz or rifampin because they may decrease Erylik®’s effectiveness.
  • Arsenic, cimetidine, diltiazem, dofetilide, HIV protease inhibitors (e.g., ritonavir), imidazoles (e.g., ketoconazole), pimozide, QT-prolonging agents (e.g., quinidine, sotalol), quinolones (e.g., ciprofloxacin), streptogramins (e.g., quinupristin/dalfopristin) may occur side effects, such as heart toxicity or irregular heartbeat.
  • Anticoagulants (e.g., warfarin), aldosterone blockers (e.g., spironolactone), alfentanil, arsenic, astemizole, benzodiazepines (e.g., alprazolam), bromocriptine, buspirone, carbamazepine, cilostazol, cisapride, clozapine, corticosteroids (e.g., hydrocortisone), cyclosporine, digitoxin, digoxin, disopyramide, ergot alkaloids (e.g., ergotamine), felodipine, H1 antagonists (e.g., diphenhydramine), HMG-CoA reductase inhibitors (e.g., simvastatin), imatinib, macrolide immunosuppressants (e.g., tacrolimus), meglitinide antidiabetics (e.g., repaglinide), midazolam, phosphodiesterase type 5 inhibitors (e.g., sildenafil), pimozide, QT-prolonging agents (e.g., quinidine, sotalol), quinolones (e.g., ciprofloxacin), rifampin, serotonin reuptake inhibitors (e.g., fluoxetine),sumatriptan, theophyllines, tricyclic antidepressants (e.g., amitriptyline), valproic acid, or vinca alkaloids (e.g., vincristine) because the risk of their side effects may be increased by Erylik® (Erythromycin, Tretinoin).

Does food or alcohol interact with Erylik® (Erythromycin, Tretinoin)?

Erylik® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Erylik® (Erythromycin, Tretinoin) ?

Erylik® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Liver disease;
  • A blood disorder called porphyria.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Erylik® (Erythromycin, Tretinoin) for an adult?

Apply topically twice a day (morning and evening) to affected areas after the skin is thoroughly washed and patted dry.

What is the dose of Erylik® (Erythromycin, Tretinoin) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Erylik® (Erythromycin, Tretinoin) available?

Erylik® is available in the following dosage forms and strengths:

  • Gel; Topical; Erythromycin 4%; Tretinoin 0.025%

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room

What should I do if I miss a dose?

If you miss a dose of Erylik®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: October 13, 2016 | Last Modified: December 19, 2019

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