Durasal CR

By Medically reviewed by Hello Doktor Medical Panel


What is Durasal CR® (salbutamol) used for?

Durasal CR® is commonly used for the relief of bronchospasm in bronchial asthmas of all types or the treatment of chronic bronchitis, emphysema.

How should I take Durasal CR® (salbutamol)?

This drug comes as a capsule. Drink with a full glass of water. Do not chew or crush. Swallow it whole.

How do I store Durasal CR® (salbutamol)?

Durasal CR® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Durasal CR® in the bathroom or the freezer. There may be different brands of Durasal CR® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Durasal CR® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Durasal CR® (salbutamol)?

Durasal CR® is contraindicated in case of:

  • Salbutamol should not be used for threatened abortion during the first or second trimester of pregnancy.
  • Salbutamol and beta-blocking drugs such as propranolol should not usually be prescribed together.
  • Salbutamol tablets are contraindicated in patients with a history of hypersensitivity to any of their components.

Patients with rare hereditary problems of galactose intolerance, the lap lactase deficiency or glucose – galactose malabsorption should not take this medicine.

Bronchodilators should not be the only or main treatment in patients with severe or unstable asthma.

Increasing use of bronchodilators in particular short-acting inhaled beta2-agonists to relieve symptoms indicates deterioration of asthma control. If patients find that short-acting relief bronchodilator treatment becomes less effective or they need more inhalations than usual, medical attention must be sought.

Salbutamol causes peripheral vasodilation which may result in reflex tachycardia and increased cardiac output

Salbutamol should only be administered cautiously to patients suffering from thyrotoxicosis after careful evaluation of the benefits and risks of treatment.

Constant monitoring of potassium levels in patients with severe asthma is essential, potentially serious hypokalemia may result from beta-2 agonist therapy.

Administration of beta agonists is associated with a rise in blood glucose. Therefore, blood glucose and lactate levels should be monitored in diabetics and diabetic treatment adjusted accordingly to meet the needs of the diabetic during tocolysis. Diabetic patients may be unable to compensate for the increase in blood glucose and the development of ketoacidosis has been reported.

Concurrent administration of corticosteroids can exaggerate this effect.

Cardiovascular effects may be seen with sympathomimetic drugs, including salbutamol. There is some evidence from post-marketing data and published literature of myocardial ischemia associated with beta agonists.

Patients with underlying severe heart disease (e.g. ischemic heart disease, arrhythmia or severe heart failure) who are receiving salbutamol should be warned to seek medical advice if they experience chest pain or other symptoms of worsening heart disease. Attention should be paid to assessment of symptoms such as dyspnea and chest pain, as they may be of either respiratory or cardiac origin.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Durasal CR® (salbutamol)?

The only side effect is a fine tremor of skeletal muscle, which occurs in some patients, usually the hands and the effects are dose related.

A few patients feel tense; this is also due to the effects on skeletal muscle and not to direct CNS stimulation.

With doses of salbutamol higher than those recommended or in patients who are unusually sensitive to beta-adrenergic stimulants, peripheral vasodilation and a compensatory increase in heart rate may occur.

Occasionally headaches have been reported. Lactic acidosis, myoclonus, pulmonary edema, hypokalemia, cardiac arrhythmias may also occur and very rarely hypersensitivity reactions including angioedema, urticaria, bronchospasm, hypotension and collapse.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Durasal CR® (salbutamol)?

Durasal CR® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with your drug, including:

  • Halogenated anesthetics
  • Anti-diabetics
  • Potassium depleting agents

Does food or alcohol interact with Durasal CR® (salbutamol)?

Durasal CR® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Durasal CR® (salbutamol)?

Durasal CR® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • Hyperthyroidism
  • Diabetes


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Durasal CR® (salbutamol).

What is the dose of Durasal CR® (salbutamol) for an adult?

The usual effective dose is 4mg three or four times per day.

If adequate bronchodilation is not obtained each single dose, may be gradually increased to as much as 8mg. However, it has been established that some patients obtain adequate relief with 2mg three or four times daily.

In elderly patients or in those known to be unusually sensitive to beta-adrenergic stimulant drugs, it is advisable to initiate treatment with 2mg three or four times per day.

What is the dose of Durasal CR® (salbutamol) for a child?

The following doses should be administered three or four times daily.

  • 2-6 years: 1-2mg
  • 6-12 years: 2mg
  • Over 12 years: 2-4mg

The dosage has not been established in pediatric patients under 2 years of age. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Durasal CR® (salbutamol) available?

Durasal CR® is available in the following dosage forms and strengths:

  • Durasal-CR® capsule 4 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Durasal CR®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

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Review Date: April 1, 2017 | Last Modified: December 19, 2019

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