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What is Arixtra® (fondaparinux) used for?

Arixtra® is used for preventing blood clots in patients who will be having certain types of surgery.

Arixtra® is also used with warfarin to treat blood clots in the leg or lungs. It may also be used for other conditions as determined by your doctor.

How should I take Arixtra® (fondaparinux)?

Use Arixtra® as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Arixtra®. Talk to your pharmacist if you have questions about this information.

Arixtra® is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using Arixtra® at home, a health care provider will teach you how to use it. Be sure you understand how to use Arixtra®. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use Arixtra® if it contains particles, is cloudy or discolored, or if the syringe is cracked or damaged.

Use the proper technique taught to you by your doctor. Inject deep under the skin, not into muscle.

Use a different injection site each day to prevent problems at the injection site (e.g., hematomas).

Ask your health care provider any questions you may have about how to use Arixtra®.

How do I store Arixtra® (fondaparinux)?

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

Precautions & warnings

What should I know before using Arixtra® (fondaparinux)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Arixtra® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have a history of kidney problems, liver problems, stomach or intestinal problems (e.g., ulcers), stroke, or vision problems caused by diabetes.
  • You have a bleeding disorder; a history of brain bleeding or blood conditions; severe, uncontrolled high blood pressure; or low body weight.
  • You have recently had or are scheduled to have brain, spine, or eye surgery; an epidural catheter; or a spinal puncture.
  • You are taking medicines that affect platelets (e.g., aspirin, clopidogrel, ticlopidine).

Arixtra® may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

Tell your doctor or dentist that you take Arixtra® before you receive any medical or dental care, emergency care, or surgery.

Arixtra® may affect certain lab tests, including liver enzyme. Be sure your doctor and lab personnel know you are using Arixtra®.

Lab tests, including complete blood cell counts (e.g., platelet counts), kidney function, and stool blood, may be performed while you use Arixtra®. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Arixtra® with caution in the elderly; they may be more sensitive to its effects, especially bleeding.

Arixtra® should be used with extreme caution in children; safety and effectiveness in children have not been confirmed. Children may have an increased risk of bleeding with Arixtra®.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Arixtra® (fondaparinux)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Mild bleeding
  • Irritation
  • Rash, or itching at the injection site
  • Trouble sleeping

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Bloody, black, tarry stools
  • Confusion
  • Difficulty walking
  • Fainting
  • Fever
  • Increased drainage or oozing from a wound
  • Loss of appetite
  • Nosebleed
  • One-sided weakness
  • Pale skin
  • Pink or red urine
  • Severe or persistent dizziness or headache
  • Severe or persistent tiredness, weakness, nausea, or vomiting
  • Slurred speech
  • Swelling of the ankles, feet, or hands
  • Tingling or numbness (especially in the legs and feet), and muscle weakness
  • Unusual or severe bleeding or bruising
  • Vomit that looks like coffee grounds

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Arixtra® (fondaparinux)?

Arixtra® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are activated protein C (e.g., drotrecogin alfa), anticoagulants (e.g., warfarin), direct factor Xa inhibitors (e.g., rivaroxaban), direct thrombin inhibitors (e.g., dabigatran), NSAIDs (e.g., ibuprofen, ketorolac, naproxen), platelet inhibitors (e.g., clopidogrel, ticlopidine), or salicylates (e.g., aspirin) because they may increase the risk of bleeding.

Does food or alcohol interact with Arixtra® (fondaparinux)?

Arixtra® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Arixtra® (fondaparinux)?

Arixtra® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Arixtra® (fondaparinux).

What is the dose of Arixtra® (fondaparinux) for an adult?

Deep Vein Thrombosis/Acute Pulmonary Embolism

<50 kg: 5 mg SC once daily

50-100 kg: 7.5 mg SC once daily

>100 kg: 10 mg SC once daily

Administer for 5-9 days; up to 26 days administered in clinical trials


>50 kg: 2.5 mg SC once daily for 5-9 days or up to 10 days following abdomonal surgery; for hip replacement, 11 days recommended and a minimum 10-14 days recommended for patients undergoing total hip or knee arthroplasty, or hip fracture surgery; administered for up to 35 days in some instances.

Heparin-Induced Thrombocytopenia (Off-label)

Prophylaxis of deep vein thrombosis (DVT) in patient with history of heparin-induced thrombocytopenia (HIT) until patient can switch to warfarin

2.5 mg SC once daily

American College of Chest Physicians (ACCP) guidelines assign low evidence rating to treatment of HIT with fondaparinux and conclude that further studies evaluating its role in HIT treatment are needed.

What is the dose of Arixtra® (fondaparinux) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Arixtra® (fondaparinux) available?

Arixtra® is available in the following dosage forms and strengths:

  • 5mg/0.5mL
  • 5mg/0.4mL
  • 5mg/0.6mL
  • 10mg/0.8mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Arixtra®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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