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Update Date 12/05/2020 . 6 mins read


What is Bristopen® (Oxacillin) used for?

Oxacillin is a penicillin antibiotic. It works by blocking the growth of the bacteria’s cell wall, resulting in the death of the bacteria.

Bristopen® is commonly used for treating infections caused by certain bacteria.

How should I take Bristopen® (Oxacillin)?

Oxacillin is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using oxacillin at home, a health care provider will teach you how to use it. Be sure you understand how to use oxacillin. Follow the procedures, you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use oxacillin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

To clear up your infection completely, use oxacillin for the full course of treatment. Keep using it even if you feel better in a few days.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

How do I store Bristopen® (Oxacillin)?

Oxacillin is usually handled and stored by a health care provider. If you are using oxacillin at home, store oxacillin as directed by your pharmacist or health care provider. Store away from heat, moisture, and light. Keep oxacillin out of the reach of children and away from pets.

Precautions & warnings

What should I know before using Bristopen® (Oxacillin)?

Before using oxacillin, tell your doctor if:

  • You are allergic to any ingredient in oxacillin or any other penicillin antibiotic (e.g., amoxicillin).
  • You are taking a tetracycline antibiotic (e.g., doxycycline).
  • You take oxacillin before you receive any medical or dental care, emergency care, or surgery.
  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.
  • You are dehydrated.
  • You have had a severe allergic reaction (e.g., severe rash, hives, difficulty breathing, dizziness) to a cephalosporin antibiotic (e.g., cephalexin) or other beta-lactam antibiotic (e.g., imipenem).
  • You are allergic to corn or corn products.

Also, you should know that:

  • Oxacillin only works against bacteria; it does not treat viral infections (e.g., the common cold).
  • Be sure to use oxacillin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of oxacillin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea, (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • Oxacillin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Hormonal birth control (e.g., birth control pills) may not work as well while you are using oxacillin. To prevent pregnancy, use an extra form of birth control (e.g., condoms).
  • Lab tests, including kidney or liver function tests, complete blood cell counts, or blood electrolyte levels, may be performed while you use oxacillin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use oxacillin with caution in the elderly; they may be more sensitive to its effects.
  • Oxacillin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.
  • Use oxacillin with extreme caution in children younger than 10 years old who have diarrhea or an infection of the stomach or bowel.

Is it safe during pregnancy or breastfeeding?


If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using oxacillin while you are pregnant.


Oxacillin is found in breast milk. If you are or will be breastfeeding while you use oxacillin, check with your doctor. Discuss any possible risks to your baby.

Side effects

What side effects can occur from Bristopen® (Oxacillin)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Mild diarrhea
  • Nausea
  • Vomiting
  • Swelling or redness at the injection site

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Itching
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Black tongue
  • Blood in the urine
  • Bloody stools
  • Chest pain
  • Dark urine
  • Fever, chills, or sore throat
  • Joint or muscle pain
  • Mouth irritation
  • Red, swollen, or blistered skin
  • Seizures
  • Severe diarrhea
  • Severe or persistent nausea or vomiting
  • Severe stomach pain/cramps
  • Swelling in the mouth
  • Swollen joints
  • Unusual bruising or bleeding
  • Vaginal irritation or discharge
  • Vein swelling or tenderness
  • Yellowing of the eyes or skin

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Bristopen® (Oxacillin)?

Bristopen®may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Tetracyclines (e.g., doxycycline)
  • Anticoagulants (e.g., warfarin)
  • Heparin or methotrexate
  • Aminoglycosides (e.g., gentamicin)
  • Oral contraceptives (birth control pills)

Does food or alcohol interact with Bristopen® (Oxacillin)?

Bristopen® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Bristopen® (Oxacillin)?

Bristopen® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Asthma
  • Kidney problems
  • Bleeding or clotting problems
  • Abnormal blood electrolyte levels
  • A low-salt diet


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Bristopen® (Oxacillin).

What is the dose of Bristopen® (Oxacillin) for an adult?

The recommended dose is PO / IV / IM 250 mg to 1 g every 4 to 6 h.

General advice

  • Administer oral doses on empty stomach at least 1 h before or 2 h after meals.
  • Reconstitute IM preparation to dilution of 250 mg/1.5 ml. Use deep, slow injection. Rotate sites to prevent tissue irritation.
  • Reconstitute IV preparation with sterile water for injection or sodium chloride for injection. Administer slowly over approximately 10 min to prevent vein irritation.

What is the dose of Bristopen® (Oxacillin) for a child?

Children (less than 40 kg)

The recommended dose is PO / IV / IM 50 to 100 mg/kg/day in divided doses every 4 to 6 h.


The recommended dose is IV / IM 25 mg/kg/day.

How is Bristopen® (Oxacillin) available?

Bristopen® is available in the following dosage forms and strengths:

  • Capsule; Oral; Oxacillin Sodium 500 mg
  • Injectable; Injection; Oxacillin Sodium 1 g
  • Powder for Syrup; Oral; Oxacillin Sodium 250 mg / 5 ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Bristopen®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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