Toplexil syrup

By Medically reviewed by Panel Perubatan Hello Doktor


What is Toplexil® (oxomemazine, guaifenesin) used for?

Toplexil® is commonly used for soothe the dry coughs and irritative coughs in adults and children over 1 year of age, in particular when they occur in the evening or at night.

How should I take Toplexil® (oxomemazine, guaifenesin)?

Take Toplexil® syrup directly as direction of doctor or pharmacist.

This drug is taken by mouth.

How do I store Toplexil® (oxomemazine, guaifenesin)?

Toplexil® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Toplexil® in the bathroom or the freezer. There may be different brands of Toplexil® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Toplexil® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Toplexil® (oxomemazine, guaifenesin)?

Before using this drug, tell your doctor if you have allergic to any ingredients of this drug.

Because of the photosensitizing effect of phenothiazines, it is preferable to avoid exposure to the sun during treatment.
In children, it is important to rule out bronchial asthma or gastroesophageal reflux before using oxomemazine as an antitussive.

Alcohol increases the sedative effect of H1 antihistamines. Impaired alertness may make driving and machinery operations dangerous. Avoid alcoholic drinks and medicines containing alcohol.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Toplexil® (oxomemazine, guaifenesin) ?

Some side effects can occur when using this drug, including:

  • Skin rash (including erythema, eczema, purpura, urticaria)
  • Edema (urticaria with sudden swelling of the face and neck which may cause difficulty breathing)
  • Anaphylactic shock
  • Sensitization of the skin to the effects of the sun
  • Fever
  • Abnormal fall in blood platelets (bleeding from the nose or gums)
  • Drowsiness
  • Impaired alertness
  • Impaired memory or concentration
  • Dizziness
  • Motor incoordination
  • Tremor
  • Confusion
  • Hallucinations
  • Dry mouth
  • Visual troubles
  • Retention of urine
  • Constipation
  • Palpitations
  • Low blood pressure

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Toplexil® (oxomemazine, guaifenesin)?

Toplexil® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Sedative antidepressants
  • Barbiturates
  • Benzodia zepines
  • Clonidine and related substances
  • Hypnotics
  • Morphine derivatives (analgesics and antitussives)
  • Methadone
  • Neuroleptics
  • Transquilizers
  • Atropine
  • Imipramine antidepressants
  • Anticholinergic parkinsonism drugs
  • Atropine­like antispasmodics
  • Disopyramide
  • Phenothiazine neuroleptics

Does food or alcohol interact with Toplexil® (oxomemazine, guaifenesin)?

Toplexil® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Toplexil® (oxomemazine, guaifenesin)?

Toplexil® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Orthostatic hypotension
  • Vertigo
  • Sedation
  • Chronic constipation (risk of paralytic ileus)
  • Prostatic hypertrophy
  • Cardio­vascular disorders
  • Severe impaired liver
  • Renal function


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Toplexil® (oxomemazine, guaifenesin).

What is the dose of Toplexil® (oxomemazine, guaifenesin) for an adult?

Adults and children weighing more than 40 kg (i.e. age 12):

The recommended dose is 10 ml per dose, 4 times a day.

What is the dose of Toplexil® (oxomemazine, guaifenesin) for a child?

Children: the daily dosage depends upon the weight of your child:

  • 10 to 20 kg (i.e. age 2 to 6): The recommended dose is 5 ml per dose, 2 to 3 times a day.
  • 20 to 30 kg (i.e. age 6 to 10): The recommended dose is 10 ml per dose, 2 to 3 times a day.
  • 30 to 40 kg (i.e. age 10 to 12): The recommended dose is 10 ml per dose, 3 to 4 times a day.

How is Toplexil® (oxomemazine, guaifenesin) available?

Toplexil® is available in the following dosage forms and strengths:

  • Toplexil® Syrup, 60 ml in brown glass bottle
  • Toplexil® Syrup, 120 ml in brown glass bottle

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Toplexil®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: February 18, 2017 | Last Modified: December 19, 2019

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