By Medically reviewed by Panel Perubatan Hello Doktor


What is tidocol (mesalamine) used for?

Tidocol is commonly used for the treatment of mild to moderate ulcerative colitis. It is also used to prevent the symptoms of ulcerative colitis from recurring.

Tidocol may also be used for other purposes, ask your doctor for more information.

How should I take tidocol (mesalamine)?

Take tidocol with a full glass of water. Tidocol should be taken with a meal.

Tidocol can be taken with or without food. Follow your doctor’s instructions or the directions on your medicine label.

Do not crush, break, or chew a tablet or capsule. Swallow the pill whole.

The extended-release capsule is specially formulated to release the medicine after it has passed through your stomach into your intestines. Breaking the pill may cause the drug to be released too early in the digestive tract.

The enteric-coated tablet has a special coating to protect your stomach. Breaking the pill could damage this coating.

Call your doctor if you find undissolved tablets in your stool.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are taking tidocol.

How do I store tidocol (mesalamine)?

Tidocol is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store tidocol in the bathroom or the freezer. There may be different brands of tidocol that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush tidocol down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using tidocol (mesalamine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of tidocol or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have hypersensitivity to mesalazine, salicylates and sulfasalazine.
  • You have severe impaired renal (CrCl < 20 ml/min) or hepatic function.

Counsel patients taking delayed release tablets to report repeatedly unbroken or partially broken tablets in their faces. Pyloric stenosis may delay release into colon.

Counsel patients to report any unexplained bleeding, bruising, purpura, sore throat, fever or malaise during treatment; perform blood count and stop treatment if blood dyscrasias suspected.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using tidocol during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking tidocol.

Side effects

What side effects can occur from tidocol (mesalamine)?

When using this drug, common side effects may include:

Stop using tidocol and call your doctor at once if you have:

  • Severe stomach pain
  • Cramping
  • Bloody diarrhea
  • Fever
  • Headache
  • Skin rash
  • Chest pain
  • Shortness of breath
  • Nausea
  • Upper stomach pain
  • Itching
  • Loss of appetite
  • Dark urine
  • Clay-colored stools
  • Jaundice (yellowing of the skin or eyes)
  • Little or no urinating
  • Swelling
  • Rapid weight gain
  • Bloody or tarry stools
  • Coughing up blood or vomit that looks like coffee grounds

Get emergency medical help if you have signs of an allergic reaction, such as hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with tidocol (mesalamine)?

Tidocol may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with your drug, including:

  • Azathioprine
  • Mercaptopurine
  • NSAIDs (nonsteroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others

Does food or alcohol interact with tidocol (mesalamine)?

Tidocol may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with tidocol (mesalamine)?

Tidocol may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • A stomach condition called pyloric stenosis
  • Heart disease
  • Kidney disease
  • Liver disease
  • A history of blockage in your digestive tract (stomach or intestines)
  • Active peptic ulcer
  • A history of pericarditis or myocarditis


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using tidocol (mesalamine).

What is the dose of tidocol (mesalamine) for an adult?

The recommended dose is 800 mg, orally 3 times a day.

Duration of therapy is 6 weeks.

What is the dose of tidocol (mesalamine) for a child?

Dose is based on:

  • 17 to less than 33 kg: The recommended dose is 36 to 71 mg/kg/day, orally, divided into 2 doses a day. Maximum dose is 1.2 g/day.
  • 33 to less than 54 kg: The recommended dose is 37 to 61 mg/kg/day, orally, divided into 2 doses a day. Maximum dose is 2 g/day.
  • 54 to 90 kg: The recommended dose is 27 to 44 mg/kg/day, orally, divided into 2 doses a day. Maximum dose is 2.4 gm/day.
  • Duration of therapy is 6 weeks.

How is tidocol (mesalamine) available?

Tidocol is available in the following dosage forms and strengths:

  • Tidocol 400mg tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of tidocol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

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Review Date: April 19, 2017 | Last Modified: December 19, 2019

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