By Medically reviewed by Hello Doktor Medical Panel


What is Rantudil® (acemetacin) used for?

Rantudil® is commonly used for treating:

Acemetacin works by blocking the effect of chemicals called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.

How should I take Rantudil® (acemetacin)?

Take acemetacin exactly as your doctor tells you to. The usual dose for adults is one 60 mg capsule taken twice daily, preferably morning and evening. If it is necessary, your doctor may increase your dose to one capsule three times daily.

Take your doses with a snack, or just after eating a meal. This will help protect your stomach from side-effects such as indigestion.

Swallow the capsules whole with a drink of water. Do not chew or open the capsules.

How do I store Rantudil® (acemetacin)?

Rantudil® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Rantudil® in the bathroom or the freezer. There may be different brands of Rantudil® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Rantudil® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Rantudil® (acemetacin)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Rantudil® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

This drug may cause dizziness, drowsiness, fatigue, and visual disturbances, if affected, do not drive or operate machinery.

Is it safe during pregnancy or breastfeeding?

Rantudil® must not be taken during the first and second trimesters of pregnancy without consulting your doctor.

Rantudil® is contraindicated during the last three trimesters due to the increased risk of serious complications for both mother and children.

Side effects

What side effects can occur from Rantudil® (acemetacin)?

Some side effects may occur when using this drug, including:

  • Nausea
  • Vomiting
  • Diarrhea
  • Flatulence
  • Constipation
  • Dyspepsia
  • Abdominal pain
  • Melena
  • Hematemesis
  • Ulcerative stomatitis
  • Gastritis
  • Asthma
  • Bronchospasm
  • Dyspnea
  • Pruritus
  • Urticaria
  • Purpura
  • Angioedema
  • Hypertension
  • Edema
  • Cardiac failure
  • Agitation
  • Headache
  • Dizziness
  • Malaise
  • Drowsiness
  • Increased hepatic enzyme
  • Alopecia
  • Retinal pigment degeneration
  • Corneal opacity

Also, it could lead to potentially fatal, such as GI bleeding, ulceration or perforation. Rarely, severe hypersensitivity reactions, including angioneurotic edema, respiratory distress which may lead to asthma attack, tachycardia or decreased BP leading to shock.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Rantudil® (acemetacin)?

Rantudil® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with your drug, including:

  • Other NSAIDs
  • Corticosteroids, anti-platelet agents, and SSRIs
  • Antacids
  • Probenecid, sulfinpyrazone
  • Diuretics and antihypertensive agents
  • Phenytoin, lithium, methotrexate
  • Nephrotoxicity, ciclosporin, and diuretics

Does food or alcohol interact with Rantudil® (acemetacin)?

Rantudil® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Rantudil® (acemetacin)?

Rantudil® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • History of GI toxicity
  • Respiratory disorder (e.g. asthma, hay fever, swollen nasal mucosae, chronic respiratory disease)
  • Uncontrolled hypertension
  • Congestive heart failure symptoms
  • Ischemic heart disease
  • Peripheral arterial disease
  • Cerebrovascular disease
  • Hyperlipidaemia
  • DM
  • Ulcerative colitis
  • Crohn’s disease
  • SLE
  • Mixed connective tissue disorders
  • Chickenpox
  • Herpes zoster
  • Parkinsonism
  • Hepatic and renal impairment
  • History of peptic ulcer/hemorrhage
  • Blood formation disorder of unclear etiology
  • Nasal polyps (associated w/ angioneurotic edema)
  • Severe heart failure


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Rantudil® (acemetacin).

What is the dose of Rantudil® (acemetacin) for an adult?

Initially, 120 mg daily in divided doses, may increase to 180 mg, based on patient response.

What is the dose of Rantudil® (acemetacin) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Rantudil® (acemetacin) available?

Rantudil® is available in the following dosage forms and strengths:

  • Forte capsules, Acemetacin 60mg
  • Retard capsules, Acemetacin 90mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Rantudil®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

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Review Date: May 9, 2017 | Last Modified: December 19, 2019

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