By Medically reviewed by Panel Perubatan Hello Doktor


What is Polaramine® (dexchlorpheniramine) used for?

Polaramine® is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.

Polaramine® is used to treat sneezing; a runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.

How should I take Polaramine® (dexchlorpheniramine)?

Take Polaramine® exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Polaramine® can be taken with or without food.

How do I store Polaramine® (dexchlorpheniramine)?

Polaramine® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Polaramine® in the bathroom or the freezer. There may be different brands of Polaramine® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Polaramine® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Polaramine® (dexchlorpheniramine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Polaramine® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Do not take dexchlorpheniramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Polaramine® (dexchlorpheniramine)?

Side effects may include:

  • Sleepiness, fatigue, or dizziness
  • Headache
  • Dry mouth
  • Difficulty urinating or an enlarged prostate

Stop taking dexchlorpheniramine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Polaramine® (dexchlorpheniramine)?

Polaramine® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Anxiety or sleep medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion)
  • Medications for depression such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil)
  • Any other medications that make you feel drowsy, sleepy, or relaxed

Does food or alcohol interact with Polaramine® (dexchlorpheniramine)?

Polaramine® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Polaramine® (dexchlorpheniramine)?

Polaramine® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Glaucoma or increased pressure in the eye
  • A stomach ulcer
  • An enlarged prostate, bladder problems, or difficulty urinating
  • An overactive thyroid (hyperthyroidism)
  • Hypertension or any type of heart problems
  • Asthma


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Polaramine® (dexchlorpheniramine).

What is the dose of Polaramine® (dexchlorpheniramine) for an adult?

Polaramine® tablets

Adults and children over 12 years: One Polaramine® tablet every 6 hours

After initial relief is obtained, dosage may be reduced to 1 tablet as required.

Polaramine® syrup

Adults and children over 12 years: 5mL every 6 hours

Children 6 to 12 years: 2 to 4mL every 6 to 8 hours

Children 4 to 6 years: 1.75 to 2mL every 6 to 8 hours

Children 2 to 4 years: 1.25 to 1.75mL every 6 to 8 hours

What is the dose of Polaramine® (dexchlorpheniramine) for a child?

Polaramine® syrup

Children 6 to 12 years: 2 to 4mL every 6 to 8 hours

Children 4 to 6 years: 1.75 to 2mL every 6 to 8 hours

Children 2 to 4 years: 1.25 to 1.75mL every 6 to 8 hours

Do not give Polaramine® syrup to children under 2 years of age.

Do not give Polaramine® tablets to children under 12 years of age.

How is Polaramine® (dexchlorpheniramine) available?

Polaramine® is available in the following dosage forms and strengths:

  • Tablet 2mg
  • Syrup 5ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Polaramine®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: August 11, 2017 | Last Modified: December 19, 2019

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