Nitazoxanide

By Medically reviewed by hellodoktor

Generic Name: Nitazoxanide Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: B

Uses

What is Nitazoxanide used for?

Nitazoxanide is used to treat diarrhea caused by certain parasite infections of the intestines (Cryptosporidium parvum and Giardia lamblia).

How should I take Nitazoxanide?

Take this medication by mouth with food as directed by your doctor, usually every 12 hours for 3 days.

If you are taking the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Children 11 years old or younger should take the liquid form of nitazoxanide, but not the tablets. For children, the dosage is based on age.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Take this drug at evenly spaced intervals.

Continue to take this medication for the full time prescribed, even if symptoms disappear after a few doses. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

How do I store Nitazoxanide?

Nitazoxanide is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Nitazoxanide in the bathroom or the freezer. There may be different brands of Nitazoxanide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Nitazoxanide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Nitazoxanide?

Before taking nitazoxanide, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, a weakened immune system (such as HIV infection).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Nitazoxanide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Nitazoxanide. Nitazoxanide is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Nitazoxanide?

This drug usually has no side effects. If you have any unusual effects, contact your doctor or pharmacist promptly.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Nitazoxanide?

Nitazoxanide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Nitazoxanide?

Nitazoxanide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Nitazoxanide?

Nitazoxanide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

The liquid form of this medication contains sugar. Caution is advised if you have diabetes. Ask your doctor or pharmacist about using this product safely.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Nitazoxanide.

What is the dose of Nitazoxanide for an adult?

Usual Adult Dose for Amebiasis

For diarrhea in immunocompetent patients: 500 mg twice daily with food for 3 days.

For diarrhea in AIDS patients: 1000 mg twice daily with food for 14 days or until diarrhea resolves.

Usual Adult Dose for Cryptosporidiosis

For diarrhea in immunocompetent patients: 500 mg twice daily with food for 3 days.

For diarrhea in AIDS patients: 1000 mg twice daily with food for 14 days or until diarrhea resolves.

Usual Adult Dose for Giardiasis

For diarrhea in immunocompetent patients: 500 mg twice daily with food for 3 days.

For diarrhea in AIDS patients: 1000 mg twice daily with food for 14 days or until diarrhea resolves.

Precautions

Caution is recommended in patients with renal and/or hepatic disease.

What is the dose of Nitazoxanide for a child?

Usual Pediatric Dose for Cryptosporidiosis

For diarrhea in immunocompetent patients:

12 to 47 months: 100 mg (5 mL) by mouth with food every 12 hours for 3 days.

4 to 11 years: 200 mg (10 mL) with food every 12 hours for 3 days.

Greater than or equal to 12 years: 500 mg twice daily with food for 3 days.

Usual Pediatric Dose for Giardiasis

For diarrhea in immunocompetent patients:

12 to 47 months: 100 mg (5 mL) by mouth with food every 12 hours for 3 days.

4 to 11 years: 200 mg (10 mL) with food every 12 hours for 3 days.

Greater than or equal to 12 years: 500 mg twice daily with food for 3 days.

Usual Pediatric Dose for Ascariasis

Study (n=105)

Dosage given orally morning and evening for 3 consecutive days.

2 to 3 years: 100 mg/5 mL

4 to 11 years: 200 mg/10 mL

Usual Pediatric Dose for Hymenolepis nana (Dwarf Tapeworm)

Study (n=105)

Dosage given orally morning and evening for 3 consecutive days.

2 to 3 years: 100 mg/5 mL

4 to 11 years: 200 mg/10 mL

Usual Pediatric Dose for Amebiasis

Study (n=53):

Greater than or equal to 12 years:

For diarrhea in immunocompetent patients: 500 mg twice daily with food for 3 days.

How is Nitazoxanide available?

Nitazoxanide is available in the following dosage forms and strengths:

  • Oral powder for reconstitution,
  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Nitazoxanide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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