By Medically reviewed by Hello Doktor Medical Panel


What is dodecavit (hydroxocobalamin acetate) used for?

Hydroxocobalamin is a vitamin. It works by increasing levels of vitamin B12 in conditions in which it is needed.

Dodecavit is commonly used for treating anemia and vitamin B12 deficiency due to some conditions, including poor diet, the Schilling test.

How should I take dodecavit (hydroxocobalamin acetate)?

Hydroxocobalamin is usually administered as an injection at your doctor’s office, hospital, or clinic. If you are using hydroxocobalamin at home, carefully follow the injection procedures taught to you by your health care provider.

If hydroxocobalamin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.

Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.

Ask your health care provider any questions you may have about how to use hydroxocobalamin.

How do I store dodecavit (hydroxocobalamin acetate)?

Dodecavit is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store dodecavit in the bathroom or the freezer. There may be different brands of dodecavit that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush dodecavit down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using dodecavit (hydroxocobalamin acetate)?

Before using this drug, tell your doctor if:

  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.

Do not take large doses of vitamins (megadoses or megavitamin therapy) unless directed to by your doctor.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using dodecavit during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking dodecavit. Dodecavit is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from dodecavit (hydroxocobalamin acetate)?

All medicines may cause side effects, but many people have no, or minor, side effects. Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Changes in blood pressure
  • Diarrhea
  • Fainting
  • Flushing
  • Itching
  • Leg pain
  • Pain or redness at the injection site
  • Swelling

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with dodecavit (hydroxocobalamin acetate)?

Dodecavit may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Especially if you are taking omeprazole, because the effectiveness of hydroxocobalamin may be decreased.

Does food or alcohol interact with dodecavit (hydroxocobalamin acetate)?

Dodecavit may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with dodecavit (hydroxocobalamin acetate)?

Dodecavit may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using dodecavit (hydroxocobalamin acetate).

What is the dose of dodecavit (hydroxocobalamin acetate) for an adult?

Cyanide poisoning: 

Note: If cyanide poisoning is suspected, antidotal therapy must be given immediately.

Initial: 5g as single infusion; may repeat a second 5 g dose depending on the severity of poisoning and clinical response. Maximum cumulative dose: 10 g.

Vitamin B12 deficiency: 

IM: Initial: 30 mcg once daily for 5-10 days; maintenance: 100-200 mcg once per month.

Note: Larger doses may be required in critically-ill patients or if patient has neurologic disease, an infectious disease, or hyperthyroidism.

What is the dose of Dodecavit (hydroxocobalamin acetate) for a child?

Vitamin B12 deficiency: 

IM: 100 mcg once daily for ≥2 weeks (total dose: 1-5 mg); maintenance: 30-50 mcg once per month.

Cyanide poisoning (off-label use): 

Note: If cyanide poisoning is suspected, antidotal therapy must be given immediately.

Initial: 70 mg/kg (maximum: 5 g) as a single infusion; may repeat a second dose of 35 mg/kg depending on the severity of poisoning and clinical response.

How is Dodecavit (hydroxocobalamin acetate) available?

Dodecavit is available in the following dosage forms and strengths:

  • Injectable; Injection; Vitamin B12 0.5 mg / ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of dodecavit, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: April 1, 2017 | Last Modified: December 19, 2019

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