By Medically reviewed by Panel Perubatan Hello Doktor


What is dhamotil (atropine sulfate, diphenoxylate HCL) used for?

Dhamotil is commonly used for treating diarrhea. It may also be used for other conditions as determined by your doctor.

How should I take dhamotil (atropine sulfate, diphenoxylate HCL)?

Use dhamotil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take dhamotil by mouth with or without food.

How do I store dhamotil (atropine sulfate, diphenoxylate HCL)?

Dhamotil is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store dhamotil in the bathroom or the freezer. There may be different brands of dhamotil that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush dhamotil down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using dhamotil (atropine sulfate, diphenoxylate HCL)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of dhamotil or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from dhamotil (atropine sulfate, diphenoxylate HCL)?

Side effects may occur when using this drug, including:

Seek medical attention right away if severe allergic reactions occur.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with dhamotil (atropine sulfate, diphenoxylate HCL)?

Dhamotil may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, such as:

  • Antihistamines (e.g., diphenhydramine)
  • Medicine for Parkinson disease (e.g., benztropine)
  • Tricyclic antidepressants (e.g., amitriptyline)
  • Barbiturates (e.g., phenobarbital)
  • Sodium oxybate (GHB)
  • Monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine)

Does food or alcohol interact with dhamotil (atropine sulfate, diphenoxylate HCL)?

Dhamotil may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with dhamotil (atropine sulfate, diphenoxylate HCL)?

Dhamotil may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions may interact with dhamotil include:

  • Diarrhea caused by certain conditions (e.g., pseudomembranous colitis, enterotoxin-producing bacteria, food poisoning)
  • Jaundice (yellowing of the eyes or skin)
  • A blockage of the stomach or bowel
  • Angle-closure glaucoma
  • Myasthenia gravis
  • Urinary blockage
  • Excess acid in the stomach or throat
  • Esophagus problems (e.g., difficulty swallowing, inflammation)
  • Bowel muscle weakness
  • Heart problems with severe bleeding


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using dhamotil (atropine sulfate, diphenoxylate HCL).

What is the dose of dhamotil (atropine sulfate, diphenoxylate HCL) for an adult?

Initial dose is 2 tablets or 10 mL (5 mg of diphenoxylate), orally, 4 times a day.

What is the dose of dhamotil (atropine sulfate, diphenoxylate HCL) for a child?

2 years and older:

Initial dose is 0.3 to 0.4 mg/kg of diphenoxylate, orally, in 4 divided doses.

How is dhamotil (atropine sulfate, diphenoxylate HCL) available?

Dhamotil is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of dhamotil, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: June 14, 2017 | Last Modified: December 19, 2019

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