Madagascar Periwinkle


Update Date 12/05/2020 . 3 mins read
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What is Madagascar periwinkle used for?

Madagascar periwinkle is a plant. The parts that grow above the ground are used to make medicine.

Despite serious safety concerns, Madagascar periwinkle is used for:

It is also used as a cough remedy, for easing lung congestion, and to reduce fluid retention by increasing urine production (as a diuretic).

Some people apply Madagascar periwinkle directly to the skin to:

  • Stop bleeding
  • Relieve insect bites, wasp stings, and eye irritation
  • Treat infections and swelling (inflammation)

How does it work?

There are not enough studies about how Madagascar periwinkle works. Please discuss with your herbalist or doctor for more information. However, it is known that:

Madagascar periwinkle might alter the immune system, increase the production of urine (diuretic), and lower blood sugar.

Vinblastine and vincristine, some chemicals that can be taken out of Madagascar periwinkle, are approved by the US Food and Drug Administration (FDA) for use in chemotherapy. These chemicals are used against cancers such as Hodgkin’s disease, leukemia, Kaposi’s sarcoma, malignant lymphomas, mycosis fungoides , neuroblastoma, and Wilm’s tumor.

Precautions & warnings

What should I know before using Madagascar periwinkle?

Consult with your doctor or pharmacist or herbalist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription.
  • You have allergy with any substances of Madagascar periwinkle or other medications or other herbs.
  • You have any other illnesses, disorders, or medical conditions.
  • You have any other types of allergies, such as to foods, dyes, preservatives, or animals.

The regulations for an herb are less strict than the regulations for a drug. More studies are needed to determine its safety. The benefits of taking this herb must outweigh the risks before use. Consult with your herbalist or doctor for more information.

How safe is Madagascar periwinkle?

Madagascar periwinkle is unsafe when taken by mouth due to the presence of poisonous chemicals known as vinca alkaloids.

There isn’t enough information to know if it is safe for use on the skin.

Special precautions & warnings

Pregnancy and breast-feeding: It’s unsafe to use Madagascar periwinkle if you are pregnant. It could cause a miscarriage or birth defects.

It’s also unsafe to use Madagascar periwinkle if you are breast-feeding, because of the poisonous chemicals it contains.

Diabetes: Madagascar periwinkle seems to be able to lower blood sugar. There is some concern that it might lower blood sugar too much in people with diabetes who are using antidiabetes medications. Medication doses might need to be changed.

Surgery: Madagascar periwinkle seems to be able to lower blood sugar levels. Some doctors worry that Madagascar periwinkle might interfere with blood sugar control during and after surgery. Stop using Madagascar periwinkle at least 2 weeks before a scheduled surgery.

Side effects

What kind of side effects may I have from Madagascar periwinkle?

Madagascar periwinkle can cause side effects such as nausea, vomiting, hair loss, hearing loss, dizziness, bleeding, nerve problems, seizures, liver damage, low blood sugar, and even death.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about side effects, please consult your herbalist or doctor.


What interactions may I have with Madagascar periwinkle?

Madagascar periwinkle may interact with your current medications or medical conditions. Consult with your herbalist or doctor before using.

Products that may interact with Madagascar periwinkle include:

  • Lithium

Madagascar periwinkle might have an effect like a water pill or “diuretic.” Taking Madagascar periwinkle might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.

  • Antidiabetes drugs

Madagascar periwinkle might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking Madagascar periwinkle along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.


The information provided is not a substitute for medical advice. ALWAYS consult your herbalist or doctor before using this medication.

What is the usual dose for Madagascar periwinkle?

The dose for Madagascar periwinkle may be different for every patient. The dose that you take depends on your age, health, and several other conditions. Herbs are not always safe. Please discuss with your herbalist or doctor for your appropriate dosage.

What form does Madagascar periwinkle come in?

Madagascar periwinkle may be available in the following forms:

  • Raw Madagascar periwinkle

Hello Health Group does not provide medical advice, diagnosis or treatment.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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