Certain medications can exacerbate or even trigger psoriasis, including lithium (used to treat bipolar disorder), beta-blockers (prescribed for heart problems), and nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin.
Sulfonamide drugs, often used to treat urinary tract infections, can have adverse interactions with methotrexate (a commonly prescribed systemic medication for psoriasis), according to Steven Feldman, MD, PhD, a professor of dermatology at Wake Forest University in Winston-Salem, N.C. They can also cause photosensitivity, making you more sensitive to the sun.
Weather changes
Climate can have a big effect on psoriasis. When the weather is colder and drier, psoriasis tends to flare. Most people find their skin is better in the summer and worse in the winter. Hot weather usually makes it better, but not always.
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