Zoledronic acid

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Uses

What is Zoledronic Acid used for?

Zoledronic Acid is commonly used to treat Paget’s disease. It is used to put off or treat soft, brittle bones (osteoporosis). It may be given to you for other reasons. Talk with the doctor.

How should I take Zoledronic Acid?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

It is given as an infusion into a vein over a period of time.

Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

Acetaminophen may be given to lower fever and chills.

Drink at least 2 glasses of liquids a few hours before you get zoledronic acid.

How do I store Zoledronic Acid?

If you need to store zoledronic acid at home, talk with your doctor, nurse, or pharmacist about how to store it.

Precautions & warnings

What should I know before using Zoledronic Acid?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Zoledronic Acid or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have low calcium levels.
  • You have kidney disease.
  • You are taking or will be taking another drug like this one.
  • You are taking another drug that has the same drug in it.
  • You are pregnant or may be pregnant. Do not take this medicine if you are pregnant.
  • You are breast-feeding or plan to breastfeed.

Tell all of your health care providers that you take zoledronic acid. This includes your doctors, nurses, pharmacists, and dentists.

Worsening of asthma has happened in people taking drugs like this one. Talk with the doctor.

This medicine may raise the chance of a broken leg. Talk with the doctor.

Have blood work checked as you have been told by the doctor. Talk with the doctor.

Have a bone density test as you have been told by your doctor. Talk with your doctor.

Take calcium and vitamin D as you were told by your doctor.

Have a dental exam before starting this medicine.

Take good care of your teeth. See a dentist often.

This medicine works best when used with calcium/vitamin D and weight-bearing workouts like walking or PT (physical therapy).

Follow the diet and workout plan that your doctor told you about.

Do not give to a child. Talk with your doctor.

If you are 65 or older, use zoledronic acid with care. You could have more side effects.

Use birth control that you can trust to prevent pregnancy while taking this medicine.

This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking zoledronic acid, call your doctor right away.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Zoledronic Acid during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Zoledronic Acid. Zoledronic Acid is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Zoledronic Acid?

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low calcium levels like muscle cramps or spasms, numbness and tingling, or seizures.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Very bad bone, joint, or muscle pain.
  • Any new or strange groin, hip, or thigh pain.
  • Chest pain.
  • A heartbeat that does not feel normal.
  • Fast or slow heartbeat.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Mouth sores.
  • Trouble swallowing.
  • Very bad pain when swallowing.
  • Fever or chills.
  • Sore throat.
  • Any unexplained bruising or bleeding.
  • Feeling very tired or weak.
  • Mood changes.
  • Pain where the shot was given.
  • Redness or swelling where the shot is given.
  • Dizziness
  • Upset stomach or throwing up.
  • Irritation where the shot is given.
  • Feeling tired or weak.
  • Belly pain.
  • Headache
  • Flu-like signs.
  • Loose stools (diarrhea).
  • Muscle or joint pain.
  • Back pain.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.

This medicine may cause jawbone problems. The chance may be higher the longer you take this medicine. The chance may be higher if you have cancer, dental problems, dentures that do not fit well, anemia, blood clotting problems, or an infection. The chance may also be higher if you are having dental work, getting chemo or radiation, or taking other drugs that may cause jawbone problems like some steroid drugs. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure. Call your doctor right away if you have jaw swelling or pain.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Zoledronic Acid?

Zoledronic Acid may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Zoledronic Acid?

Zoledronic Acid may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Zoledronic Acid?

Zoledronic Acid may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Zoledronic Acid.

What is the dose of Zoledronic Acid for an adult?

Usual Adult Dose for Osteolytic Bone Lesions of Multiple Myeloma

Zometa(R): 4 mg IV over no less than 15 minutes, every 3 to 4 weeks

Usual Adult Dose for Osteolytic Bone Metastases of Solid Tumors

Zometa(R): 4 mg IV over no less than 15 minutes, every 3 to 4 weeks

Usual Adult Dose for Hypercalcemia of Malignancy

Zometa(R): Maximum dose: Single dose of 4 mg IV infusion over no less than 15 minutes

Usual Adult Dose for Paget’s Disease

Reclast(R): 5 mg IV infusion, at a constant infusion rate, over no less than 15 minutes

Calcium and vitamin D supplementation:

  • Calcium: 750 mg elemental calcium orally twice a day, or 500 mg orally three times a day
  • Vitamin D: 800 international units orally daily, especially in the 2 weeks following drug administration

Usual Adult Dose for Osteoporosis

Reclast(R): 5 mg IV infusion over no less than 15 minutes, once a year

Usual Adult Dose for Prevention of Osteoporosis

Reclast(R): 5 mg IV infusion over no less than 15 minutes, every 2 years

What is the dose of Zoledronic Acid for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Zoledronic Acid available?

Zoledronic Acid is available in the following dosage forms and strengths:

  • Intravenous solution
  • Intravenous powder for injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Zoledronic Acid, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: November 20, 2017 | Last Modified: December 19, 2019

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