By Medically reviewed by Hello Doktor Medical Panel


What is Zinacef® (Cefuroxime) used for?

Zinacef® is a cephalosporin antibiotic. It works by killing sensitive bacteria, treating bacterial infections or preventing bacterial infections before, during, or after certain surgeries.

How should I take Zinacef® (Cefuroxime)?

Use Zinacef® as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Zinacef® is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using Zinacef® at home, a health care provider will teach you how to use it. Be sure you understand how to use Zinacef®. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • To clear up your infection completely, use Zinacef® for the full course of treatment. Keep using it even if you feel better in a few days.
  • Do not use Zinacef® if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

How do I store Zinacef® (Cefuroxime)?

Zinacef® is usually handled and stored by a health care provider. If you are using Zinacef® at home, store Zinacef® as directed by your pharmacist or health care provider.

Precautions & warnings

What should I know before using Zinacef® (Cefuroxime)?

Before using cefuroxime, tell your doctor or pharmacist if:

  • You are allergic to it, or to other cephalosporins, or to penicillins, or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
  • You have a medical history, especially of kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis).

Tell your doctor if you are pregnant before using this medication.

Is it safe during pregnancy or breastfeeding?


If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zinacef® while you are pregnant.


Zinacef® is found in breast milk. If you are or will be breastfeeding while using Zinacef®, check with your doctor. Discuss any possible risks to your baby.

Side effects

What side effects can occur from Zinacef® (Cefuroxime)?

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Pain
  • Swelling
  • Redness at the injection site

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Black or bloody stools
  • Decreased urination
  • Fever
  • Chills
  • Sore throat
  • Hearing loss
  • Seizures
  • Severe diarrhea
  • Nausea
  • Vomiting
  • Stomach pain
  • Cramps
  • Unusual bruising
  • Bleeding
  • Vaginal irritation or discharge
  • Vein swelling at the injection site
  • Yellowing of the skin or eyes


What drugs may interact with Zinacef® (Cefuroxime)?

Some medicines may interact with Zinacef®, including:

  • Aminoglycosides (e.g., tobramycin) or diuretics (e.g., furosemide) because the risk of kidney problems may be increased.
  • Anticoagulants (e.g., warfarin) because the risk of their side effects may be increased by Zinacef®.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zinacef® interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Does food or alcohol interact with Zinacef® (Cefuroxime)?

Zinacef® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Zinacef® (Cefuroxime)?

Zinacef® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Zinacef® (Cefuroxime).

What is the dose of Zinacef® (Cefuroxime) for an adult?

The usual adult dosage for Znacef® is 750 mg to 1.5 grams every 8 hours, usually for 5 to 10 days. In uncomplicated urinary tract infections, skin and skin‑structure infections, disseminated gonococcal infections, and uncomplicated pneumonia, a 750-mg dose every 8 hours is recommended. In severe or complicated infections, a 1.5-gram dose every 8 hours is recommended.

In bone and joint infections, a 1.5-gram dose every 8 hours is recommended. In clinical trials, surgical intervention was performed when indicated as an adjunct to therapy with Zinacef®. A course of oral antibiotics was administered when appropriate following the completion of parenteral administration of Zinacef®.

In life-threatening infections or infections due to less susceptible organisms, 1.5 grams every 6 hours may be required. In bacterial meningitis, the dosage should not exceed 3 grams every 8 hours. The recommended dosage for uncomplicated gonococcal infection is 1.5 grams given intramuscularly as a single dose at 2 different sites together with 1 gram of oral probenecid. For preventive use for clean-contaminated or potentially contaminated surgical procedures, a 1.5-gram dose administered intravenously just before surgery (approximately one-half to 1 hour before the initial incision) is recommended. Thereafter, give 750 mg intravenously or intramuscularly every 8 hours when the procedure is prolonged.

For preventive use during open heart surgery, a 1.5-gram dose administered intravenously at the induction of anesthesia and every 12 hours thereafter for a total of 6 grams is recommended.

A reduced dosage must be employed when renal function is impaired.

What is the dose of Zinacef® (Cefuroxime) for a child?

Pediatric patients above 3 months of age

Administration of 50 to 100 mg/kg/day in equally divided doses every 6 to 8 hours has been successful for most infections susceptible to cefuroxime. The higher dosage of 100 mg/kg/day (not to exceed the maximum adult dosage) should be used for the more severe or serious infections.

In bone and joint infections, 150 mg/kg/day (not to exceed the maximum adult dosage) is recommended in equally divided doses every 8 hours. In clinical trials, a course of oral antibiotics was administered to pediatric patients following the completion of parenteral administration of Zinacef®.

In cases of bacterial meningitis, a larger dosage of Zinacef® is recommended, 200 to 240 mg/kg/day intravenously in divided doses every 6 to 8 hours.

In pediatric patients with renal insufficiency, the frequency of dosing should be modified consistent with the recommendations for adults.

How is Zinacef® (Cefuroxime) available?

Zinacef® ® is available in the following dosage forms and strengths:

  • Cefuroxime (as sodium) 750mg, 1.5g; IM or IV inj; sodium content 2.4mEq/g.

What should I do in case of an emergency or overdose?

Over dosage of cefuroxime can cause cerebral irritation leading to convulsions. Serum levels of cefuroxime can be reduced by hemodialysis and peritoneal dialysis. In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Zinacef®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: December 16, 2016 | Last Modified: December 19, 2019

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