By Medically reviewed by Hello Doktor Medical Panel


What is Toujeo® (insulin glargine) used for?

Toujeo® is a man-made form of a hormone that is produced in the body. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin glargine is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours.

The Toujeo® SoloStar injection pen is used to improve blood sugar control in adults and children with diabetes mellitus. Some brands of this medicine are for use only in adults. Carefully follow all instructions for the brand of insulin glargine you are using.

Toujeo® is used to treat type 2 diabetes in adults.

Toujeo® is also used to treat type 1 diabetes in adults and children who are at least 6 years old.

How should I take Toujeo® (insulin glargine)?

Use Toujeo® exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

The Toujeo® brand of insulin glargine contains 3 times as much insulin per milliliter (mL) as the Lantus or Basaglar brands. There are 300 units of insulin in 1 mL of Toujeo, and 100 units in 1 mL of Lantus or Basaglar.

If there are any changes in the brand, strength, or type of insulin you use, your dosage needs may change.

Insulin is injected under the skin. You will be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and injection pens.

Toujeo® must not be given with an insulin pump, or mixed with other insulins. Do not inject insulin glargine into a vein or a muscle.

Toujeo® is usually injected once per day at the same time each day. You will be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and injection pens.

Your care provider will show you the best places on your body to inject Toujeo®. Use a different place each time you give an injection. Do not inject into the same place two times in a row.

Use only the SoloStar injection pen that comes with Toujeo®. Attach a new needle before each use. Do not transfer the insulin from the SoloStar pen into a syringe.

Never share an injection pen with another person, even if the needle has been changed. Sharing these devices can allow infections or disease to pass from one person to another.

Use a disposable needle only once. Follow any state or local laws about throwing away used needles and injection pens. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.

Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your insulin dose or schedule.

Toujeo® is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor’s instructions very closely.

How do I store Toujeo® (insulin glargine)?

Keep this medicine in its original container protected from heat and light. Do not freeze insulin or store it near the cooling element in a refrigerator. Throw away any insulin that has been frozen.

Storing unopened (not in use) Toujeo® SoloStar pens:

  • Refrigerate and use until expiration date.

Storing opened (in use) Toujeo® SoloStar pens:

  • Store the injection pen at room temperature (do not refrigerate) and use within 42 days.
  • Do not store a Toujeo® SoloStar injection pen with the needle attached.

Do not use the medicine if it looks cloudy, has changed colors, or has any particles in it. Call your pharmacist for new medicine.

Precautions & warnings

What should I know before using Toujeo® (insulin glargine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Toujeo® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not use Toujeo® if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

Toujeo® should not be given to a child younger than 6 years old. Toujeo® should not be used to treat type 2 diabetes in a child of any age.

To make sure Toujeo® is safe for you, tell your doctor if you have:

  • Liver or kidney disease
  • Low levels of potassium in your blood (hypokalemia)
  • Diabetic ketoacidosis (call your doctor for treatment)

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Toujeo® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Toujeo®. Toujeo® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Toujeo® (insulin glargine)?

Get emergency medical help if you have signs of an allergy reaction to Toujeo®: redness or swelling where an injection was given, itchy skin rash over the entire body, trouble breathing, fast heartbeats, feeling like you might pass out, or swelling in your tongue or throat.

Call your doctor at once if you have:

  • Fluid retention – weight gain, swelling in your hands or feet, feeling short of breath
  • Low potassium – leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling

Common side effects may include:

  • Low blood sugar
  • Itching, mild skin rash
  • Thickening or hollowing of the skin where you injected the medicine

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Toujeo® (insulin glargine)?

Toujeo® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Toujeo® (insulin glargine)?

Toujeo® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Toujeo® (insulin glargine)?

Toujeo® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Toujeo® (insulin glargine).

What is the dose of Toujeo® (insulin glargine) for an adult?

Starting Dose in Insulin-Naïve Patients

Type 1 Diabetes:

The recommended starting dose of Toujeo® in insulin naïve patients with type 1 diabetes is approximately one-third to one-half of the total daily insulin dose. The remainder of the total daily insulin dose should be given as a short-acting insulin and divided between each daily meal. As a general rule, 0.2 to 0.4 units of insulin per kilogram of body weight can be used to calculate the initial total daily insulin dose in insulin naïve patients with type 1 diabetes.

The maximum glucose lowering effect of a dose of Toujeo® may take five days to fully manifest and the first Toujeo® dose may be insufficient to cover metabolic needs in the first 24 hours of use. To minimize risks associated with insufficient insulinization when initiating TOUJEO, monitor glucose daily, titrate Toujeo® per instructions, and adjust co-administered glucose lowering therapies per standard of care.

Type 2 Diabetes:

The recommended starting dose of Toujeo® in insulin naïve patients with type 2 diabetes is 0.2 units per kilogram of body weight once daily. The dosage of other anti-diabetic drugs may need to be adjusted when starting Toujeo® to minimize the risk of hypoglycemia.

Starting Dose in Patients with either Type 1 or Type 2 Diabetes Already on Insulin Therapy

To minimize the risk of hypoglycemia when changing patients from a once daily long-acting or intermediate acting insulin product to Toujeo®, the starting dose of Toujeo® can be the same as the once daily long-acting dose. For patients controlled on LANTUS (insulin glargine, 100 units/mL) expect that a higher daily dose of Toujeo® will be needed to maintain the same level of glycemic control.

To minimize the risk of hypoglycemia when changing patients from twice-daily NPH insulin to once-daily Toujeo®, the recommended starting Toujeo® dose is 80% of the total daily NPH dosage.

To minimize the risk of hyperglycemia when changing patients to Toujeo®, monitor glucose frequently in the first weeks of therapy titrate the dose of Toujeo® per instructions and the dose of other glucose lowering therapies per standard of care.

What is the dose of Toujeo® (insulin glargine) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Toujeo® (insulin glargine) available?

Toujeo® is available in the following dosage forms and strengths:

  • Injection, solution: insulin glargine 300U in 1mL

 What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Toujeo®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: August 29, 2017 | Last Modified: December 19, 2019

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