By Medically reviewed by Hello Doktor Medical Panel


What is Provironum® (mesterolone) used for?

Provironum® is commonly used for:

  • Reduced efficiency in middle and advanced age (such as androgen deficiency, lack of concentration, weak memory, disturbances of libido and potency, irritability, sleep disturbances, depressive moods and general vegetative complaints)
  • Potency disturbances
  • Hypogonadism
  • Infertility

How should I take Provironum® (mesterolone)?

  • Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet.
  • If you do not understand the instructions printed on the pharmacist label, ask your doctor or pharmacist for help.
  • Swallow the tablet whole with water.
  • Taking it at the same time each day will have the best effect. It will also help you remember when to take it. It does not matter if you take this medicine before or after food.

How do I store Provironum® (mesterolone)?

Provironum® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Provironum® in the bathroom or the freezer. There may be different brands of Provironum® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Provironum® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Provironum® (mesterolone)?

Do not take Provironum® if you have an allergy to:

  • Mesterolone – active ingredient in Provironum®

Do not use this medicine if the packaging is torn or shows signs of tampering. If the packaging is damaged, return it to your pharmacist for disposal.

Is it safe during pregnancy or breastfeeding?

Provironum® is used in men.

Side effects

What side effects can occur from Provironum® (mesterolone)?

Tell your doctor or pharmacist if you notice any of the following and they worry you:

  • Headache
  • Fluid retention
  • Breast enlargement
  • Increased sexual drive
  • Psychiatric disturbances (such as depression, aggression, increased or decreased energy levels, elation or irritability)
  • Acne
  • Excessive hairiness
  • Premature puberty
  • Stunted growth

Tell your doctor immediately, or go to Accident and Emergency department at your nearest hospital if you notice any of the following:

  • An enlarged prostate (such as changes in urination, or blood in the urine or ejaculate)
  • Unwanted, frequent or prolonged and painful erections
  • Severe stomach pain or tenderness

Hormonal substances such as Provironum® may quicken the growth of existing hormone dependent tissues and tumors. If you are over 65 years of age, you may have an increased risk of developing prostatic hyperplasia (enlargement of the prostate) and prostatic cancer.


What drugs may interact with Provironum® (mesterolone)?

Provironum® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Provironum® (mesterolone)?

Provironum® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Provironum® (mesterolone)?

Provironum® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Tell your doctor if you have or have had any of the following medical conditions:

  • Prostate disease
  • Liver disease
  • Heart or blood vessel disease
  • High blood pressure
  • Kidney disease
  • Difficulty passing urine
  • Migraines
  • Epilepsy
  • Diabetes
  • Sleep apnoea (abnormal pauses in breathing during sleep)
  • Polycythaemia
  • Porphyria


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Provironum® (mesterolone).

What is the dose of Provironum® (mesterolone) for an adult?

Reduced efficiency and potency disturbances

Commencement of treatment: 1 tab 3 times daily. The dose may be reduced after a satisfactory clinical improvement.

Continuation of treatment: 1 tab once or twice daily.

According to the type and severity of the complaints, the dose for further treatment is to be adjusted to individual requirements. Continuous treatment over a period of several months is recommended.

Hypogonadism requires continuous therapy

Development of secondary male sex characteristics: 1-2 tab 3 times daily for several months.

Maintenance dose: 1 tab 2-3 times daily will often be sufficient.


Improvement of sperm quantity and quality: 1 tab 2-3 times daily for a cycle of spermatogenesis, for about 90 days. If necessary, treatment is to be repeated after an interval of several weeks.

To achieve a higher fructose concentration in the ejaculate, in cases of postpubertal Leydig-cell insufficiency, 1 tab twice daily over several months.

What is the dose of Provironum® (mesterolone) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Provironum® (mesterolone) available?

Provironum® is available in the following dosage forms and strengths:

  • Tablets; Oral; Mesterolone 25 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Provironum®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: December 26, 2016 | Last Modified: December 19, 2019

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