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What is Pantoloc® (pantoprazole) used for?

Pantoloc® is commonly used for treatment conditions such as stomach ulcers, intestinal ulcers, and gastroesophageal reflux disease (GERD, reflux esophagitis) by reducing the amount of acid that your stomach produces. Pantoprazole is also sometimes used along with antibiotics to treat stomach ulcers that are caused by bacteria known as H. pylori.

Pantoloc® can also be used to treat or reduce the risk of stomach ulcers due to medications known as nonsteroidal anti-inflammatory drugs (NSAIDs), which irritate the stomach.

How should I take Pantoloc® (pantoprazole)?

Take this medication by mouth as directed by your doctor, usually once daily. Dosage and length of treatment are based on your medical condition and response to treatment.

Taking the tablet in the morning, you may take them with or without food. Swallow the tablets whole. Do not split, crush, or chew the medication.

If needed, antacids may be taken along with this medication. If you are also taking sucralfate, take pantoprazole at least 30 minutes before sucralfate.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Continue to take this medication for the prescribed length of treatment even if you are feeling better.

How do I store Pantoloc® (pantoprazole)?

Pantoloc® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Pantoloc® in the bathroom or the freezer. There may be different brands of Pantoloc® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Pantoloc® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Pantoloc® (pantoprazole)?

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have some symptoms like:

  • Chest pain or heavy feeling
  • Pain spreading to the arm or shoulder
  • Nausea
  • Sweating
  • Feeling ill

You should not use this medicine if you are allergic to pantoprazole or to similar medicines such as lansoprazole (Prevacid), esomeprazole (Nexium), omeprazole (Prilosec, Zegerid), or rabeprazole (AcipHex).

To make sure pantoprazole is safe for you, tell your doctor if you have:

  • Severe liver disease
  • Low levels of magnesium in your blood
  • Osteoporosis
  • Low bone mineral density (osteopenia)

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Pantoloc® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Pantoloc® (pantoprazole)?

Get emergency medical help if you have signs of an allergic reaction to pantoprazole:

  • Hives
  • Difficulty breathing
  • Swelling of your face, lips, tongue, or throat

Call your doctor at once if you have:

  • Severe stomach pain
  • Nausea
  • Vomiting
  • Weight loss
  • Diarrhea that is watery or bloody
  • Seizure (convulsions)
  • Kidney problems such as urinating more or less than usual, blood in your urine
  • Rapid weight gain
  • Symptoms of low magnesium – dizziness, confusion
  • Fast or uneven heart rate
  • Tremors (shaking) or jerking muscle movements
  • Feeling jittery
  • Muscle cramps
  • Muscle spasms in your hands and feet
  • Cough or choking feeling

Common pantoprazole side effects may include:

  • Headache
  • Fever
  • Cold symptoms such as stuffy nose, sneezing, sore throat
  • Stomach pain
  • Gas
  • Nausea
  • Vomiting
  • Mild diarrhea
  • Joint pain



What drugs may interact with Pantoloc® (pantoprazole)?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with pantoprazole, especially:

  • Ampicillin
  • Ketoconazole
  • Methotrexate
  • Mycophenolate mofetil
  • Warfarin (Coumadin, Jantoven)
  • HIV or AIDS medicine – atazanavir, nelfinavir
  • Iron – containing medicines – ferrous fumarate, ferrous gluconate, ferrous sulfate

This list is not complete. Other drugs may interact with pantoprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Does food or alcohol interact with Pantoloc® (pantoprazole)?

Pantoloc® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Pantoloc® (pantoprazole)?

Pantoloc® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Pantoloc® (pantoprazole).

What is the dose of Pantoloc® (pantoprazole) for an adult?

Gastroesophageal reflux disease

Oral, 40 mg per day for up to eight weeks. An additional eight-week course may be considered in patients who have not healed after four to eight weeks of treatment.

Gastroesophageal reflux disease (prophylaxis)

Oral, 20 mg once a day in the morning. Dose can be increased to 40 mg once a day in the morning in the case of recurrence.

Ulcer, duodenal, H. pylori–associated

Oral, triple therapy regimens of pantoprazole 40 mg, plus clarithromycin 500 mg, plus either amoxicillin 1000 mg or metronidazole 500 mg, in which all three medications are taken two times a day for seven days.

Ulcer, duodenal

Oral, 40 mg per day for up to two weeks. An additional two–week course may be considered in patients who have not healed after two weeks of treatment.

Ulcer, gastric

Oral, 40 mg per day for up to four weeks. An additional four–week course may be considered in patients who have not healed after four weeks of treatment.

What is the dose of Pantoloc® (pantoprazole) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Pantoloc® (pantoprazole) available?

Pantoloc® is available in the following dosage forms and strengths:

  • Tablet 40mg
  • Tablet 20mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

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