By Medically reviewed by Hello Doktor Medical Panel


What is Oflocet® (ofloxacin) used for?

Ofloxacin is a fluoroquinolone antibiotic. It kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Oflocet® is commonly used for treating mild to moderate infections caused by certain bacteria.

How should I take Oflocet® (ofloxacin)?

Use ofloxacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take ofloxacin by mouth with or without food.
  • Take ofloxacin with a full glass of water (240 ml). Drink several glasses of water daily, unless otherwise instructed by your doctor.
  • Do not drink milk or eat dairy products, or take antacids, didanosine, sucralfate, or vitamins within 2 hours before or after taking ofloxacin.
  • Ofloxacin works best if it is taken at the same time each day.
  • To clear up your infection completely, take ofloxacin for the full course of treatment. Keep taking it even if you feel better in a few days.

How do I store Oflocet® (ofloxacin)?

Oflocet® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Oflocet® in the bathroom or the freezer. There may be different brands of Oflocet® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Oflocet® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Oflocet® (ofloxacin)?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in ofloxacin or any other fluoroquinolone antibiotic (e.g., ciprofloxacin).
  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.

Also, there are some important safety information that you may notice, including:

  • Ofloxacin may cause drowsiness, dizziness, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use ofloxacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Ofloxacin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to ofloxacin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Diabetes patients – Ofloxacin may affect your blood sugar when taken along with insulin or other medicines for diabetes. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Tell your doctor or dentist that you take ofloxacin before you receive any medical or dental care, emergency care, or surgery.
  • Ofloxacin only works against bacteria; it does not treat viral infections (e.g., the common cold).
  • Long-term or repeated use of ofloxacin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • If you experience pain or inflammation, or rupture a tendon during or shortly after taking ofloxacin, contact your health care provider immediately.
  • Be sure to use ofloxacin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Lab tests, including kidney function, may be performed while you use ofloxacin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use ofloxacin with caution in the elderly; they may be more sensitive to its effects (e.g., tendon problems), especially if they take corticosteroids (e.g., prednisone). They may also be more sensitive to other effects (e.g., irregular heartbeat).
  • Ofloxacin should not be used in children younger than 18 years; safety and effectiveness in these children have not been confirmed.

Is it safe during pregnancy or breastfeeding?


 If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking ofloxacin while you are pregnant.


Ofloxacin is found in breast milk. Do not breastfeed while taking ofloxacin.

Side effects

What side effects can occur from Oflocet® (ofloxacin)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Diarrhea
  • Dizziness
  • Headache
  • Loss of appetite
  • Nausea
  • Sensitivity to sunlight
  • Trouble sleeping
  • Vomiting

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Itching
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Unusual hoarseness
  • Agitation
  • Anxiety
  • Bizarre behavior
  • Bloody stools
  • Confusion
  • Convulsions
  • Dark urine
  • Decreased urination
  • Depression
  • Diarrhea (severe or continuing)
  • Difficulty swallowing
  • Excessive urination, thirst, or hunger
  • Fainting
  • Fast or irregular heartbeat
  • Fatigue
  • Fever, chills, or unusual cough
  • Hallucinations
  • Joint pain or swelling
  • Light-headedness
  • Loss of consciousness
  • Mental or mood changes
  • Nervousness
  • Nightmares
  • Pale stools
  • Red, swollen, blistered, or peeling skin
  • Restlessness
  • Seizures
  • Shock (pale skin)
  • Sleeplessness
  • Severe or persistent stomach pain or cramps
  • Shortness of breath or trouble breathing
  • Suicidal thoughts
  • Tendon pain, inflammation, or swelling
  • Tightness of the throat
  • Tremors
  • Unusual bruising or bleeding
  • Unusual tiredness or weakness
  • Vaginal irritation or discharge
  • Yellowing of the skin or eyes

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Oflocet® (ofloxacin)?

Oflocet® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Antiarrhythmics (e.g., amiodarone, disopyramide, dofetilide, quinidine, sotalol)
  • Cisapride
  • Diuretics (e.g., furosemide, hydrochlorothiazide)
  • Macrolide or ketolide antibiotics (e.g., erythromycin, telithromycin)
  • Phenothiazines (e.g., chlorpromazine)
  • Tricyclic antidepressants (e.g., amitriptyline)
  • Corticosteroids (e.g., prednisone)
  • Foscarnet
  • NSAIDs (e.g., ibuprofen)
  • Tramadol
  • Insulin or other medicines for diabetes (e.g., glipizide)
  • Anticoagulants (e.g., warfarin)
  • Procainamide
  • Theophylline
  • Live typhoid
  • Aluminum salts (e.g., aluminum hydroxide)
  • Iron salts (oral) (e.g., ferrous sulfate)
  • Magnesium salts (e.g., magnesium hydroxide)

Does food or alcohol interact with Oflocet® (ofloxacin)?

Oflocet® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Oflocet® (ofloxacin)?

Oflocet® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Diabetes
  • Liver problems
  • A recent heart attack
  • Heart problems (e.g., angina)
  • Irregular heartbeat (e.g., QT prolongation)
  • Alzheimer disease
  • Seizures
  • Central nervous system disorder
  • Joint or tendon problems
  • Rheumatoid arthritis
  • Kidney problems
  • Kidney function
  • Lung transplant
  • Myasthenia gravis
  • Abnormal blood electrolyte levels (e.g., low potassium or magnesium)


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Oflocet® (ofloxacin).

What is the dose of Oflocet® (ofloxacin) for an adult?

Bronchitis exacerbation

The recommended dose is 400 mg PO q12hr for 10 days.

Skin structure infections

The recommended dose is 400 mg PO q12hr for 10 days.

Nongonococcal cervicitis/urethritis or mixed infection of cervix/urethra

The recommended dose is 300 mg PO q12hr for 7 days.

Acute pelvic inflammatory disease

The recommended dose is 400 mg PO q12hr for 10-14 days.

Uncomplicated Cystitis

Due to E. coli or K. pneumoniae: The recommended dose is 200 mg PO q12hr for 3 days.

Due to other approved pathogens: The recommended dose is 200 mg PO q12hr for 7 days.

Complicated UTIs

The recommended dose is 200 mg PO q12hr for 10 days.

Prostatitis due to E. Coli

The recommended dose is 300 mg PO q12hr for 6 weeks.

Traveler’s Diarrhea (Off-label)

The recommended dose is 300 mg PO q12hr for 1-3 days.

Renal impairment

  • CrCl 20-50 ml/min: Give q24hr.
  • CrCl <20 ml/min: Give one-half usual dose q24hr.

What is the dose of Oflocet® (ofloxacin) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Oflocet® (ofloxacin) available?

Oflocet® is available in the following dosage forms and strengths:

  • Tablet, Film-Coated; 200 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Oflocet®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: February 18, 2017 | Last Modified: December 19, 2019

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