Nexafed (Decongestants, Oral)

By Medically reviewed by Hello Doktor Medical Panel


What is Nexafed® (Pseudoephedrine hydrochloride) used for?

Nexafed® is commonly used for the relief of stuffy nose and sinus pain/pressure caused by infection (such as the common cold, flu) or other breathing illnesses (such as hay fever, allergies, bronchitis).

How should I take Nexafed® (Pseudoephedrine hydrochloride)?

For orally taken form, you should:

  • Take Nexafed® by mouth as directed by your doctor concerning: dose, schedule.
  • Read the label carefully before using Nexafed®.
  • Consult your doctor for any information on the label that you do not clearly understand.

How do I store Nexafed® (Pseudoephedrine hydrochloride)?

Nexafed® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Nexafed® in the bathroom or the freezer. There may be different brands of Nexafed® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Nexafed® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Nexafed® (Pseudoephedrine hydrochloride)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicine.
  • You have allergy with any of active or inactive ingredients of Nexafed® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Nexafed® during pregnancy and breast-feeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Nexafed®.

Side effects

What side effects can occur from Nexafed® (Pseudoephedrine hydrochloride)?

Some of side effects are listed below:

  • Allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat
  • Fast, pounding, or uneven heartbeat
  • Severe dizziness or anxiety
  • Easy bruising or bleeding
  • Unusual weakness
  • Fever
  • Chills
  • Body aches
  • Flu symptoms
  • Dangerously high blood pressure (severe headache, blurred vision, ringing in your ears, anxiety, confusion, chest pain, trouble breathing, uneven heart rate, seizure)
  • Loss of appetite
  • Warmth, tingling, or redness under your skin
  • Feeling restless or excited (especially in children)
  • Sleep problems (insomnia)
  • Skin rash or itching

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Nexafed® (Pseudoephedrine hydrochloride) ?

Nexafed® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval

Products that may interact with this drug are:

  • Clorgyline
  • Dihydroergotamine
  • Furazolidone
  • Iproniazid
  • Isocarboxazid
  • Linezolid
  • Moclobemide
  • Nialamide
  • Pargyline
  • Phenelzine
  • Procarbazine
  • Rasagiline
  • Selegiline
  • Toloxatone
  • Tranylcypromine
  • Guanethidine
  • Methyldopa
  • Midodrine

Does food or alcohol interact with Nexafed® (Pseudoephedrine hydrochloride)?

Nexafed® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Nexafed® (Pseudoephedrine hydrochloride)?

Nexafed® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Nexafed® (Pseudoephedrine hydrochloride).

What is the dose of Nexafed® (Pseudoephedrine hydrochloride) for an adult?

The recommended dose for adult is 30 to 60 mg orally every 4 to 6 hours as needed. The maximum daily dose is 240 mg/day.

What is the dose of Nexafed® (Pseudoephedrine hydrochloride) for a child?

For children from 2 years to 5 years, the recommended dose is 15 mg every 6 hours. The maximum daily dose is 60 mg/day.

For children from 6 years to 12 years, the recommended dose is 30 mg every 6 hours. The maximum daily dose is 120 mg/day.

For children over 12 years, the recommended dose is 30 to 60 mg orally every 4 to 6 hours as needed. The maximum daily dose is 240 mg/day.

How is Nexafed® (Pseudoephedrine hydrochloride) available?

Nexafed® is available in the following dosage forms and strengths:

  • Tablet 30 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Nexafed®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: June 29, 2017 | Last Modified: December 19, 2019

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