By Medically reviewed by Panel Perubatan Hello Doktor


What is lopril (captopril) used for?

Lopril is used to treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack.

How should I take lopril (captopril)?

Lopril is usually taken 1 hour before meals. Drink plenty of water each day while you are taking captopril.

How do I store lopril (captopril)?

Lopril is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store lopril in the bathroom or the freezer. There may be different brands of lopril that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush lopril down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using lopril (captopril)?

While using this drug, you should notice that:

  • Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking captopril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.
  • Your blood pressure will need to be checked often, and you may need frequent blood tests.
  • This medication can cause false results with certain medical tests. Tell any doctor who treats you that you are using captopril.
  • If you need surgery, tell the surgeon ahead of time that you are using captopril. You may need to stop using the medicine for a short time.
  • If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Is it safe during pregnancy or breastfeeding?


Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Captopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.


Captopril can pass into breast milk and may harm a nursing baby. You should not breastfeed while you are using captopril.

Side effects

What side effects can occur from lopril (captopril)?

Get emergency medical help if you have signs of an allergic reaction to captopril:

  • Hives
  • Severe stomach pain
  • Difficulty breathing
  • Swelling of your face, lips, tongue, or throat

Call your doctor at once if you have:

  • A light-headed feeling
  • Little or no urinating, or urinating more than usual
  • Shortness of breath (even with mild exertion)
  • Swelling
  • Rapid weight gain
  • Chest pain or pressure
  • Pounding heartbeats or fluttering in your chest
  • High potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling)
  • Sudden weakness or ill feeling
  • Fever
  • Chills
  • Sore throat
  • Painful mouth sores
  • Pain when swallowing
  • Skin sores
  • Cold or flu symptoms

Common captopril side effects may include:

  • Cough
  • Flushing (warmth, redness, or tingly feeling)
  • Numbness, tingling, or burning pain in your hands or feet
  • Loss of taste sensation
  • Mild skin itching or rash

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with lopril (captopril)?

Lopril may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Aliskiren
  • Everolimus
  • Sirolimus
  • Lithium
  • ARBs including losartan/valsartan
  • Birth control pills containing drospirenone
  • Sacubitril
  • ACE inhibitor, such as benazepril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril

Does food or alcohol interact with lopril (captopril)?

Lopril may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with lopril (captopril)?

Lopril may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Kidney disease (or if you are on dialysis)
  • Liver disease
  • Diabetes
  • A connective tissue disease (such as Marfan syndrome, Sjogren’s syndrome, lupus, scleroderma, or rheumatoid arthritis)
  • Organ transplant


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using lopril (captopril).

What is the dose of lopril (captopril) for an adult?


Initial dose: 25 mg orally 2 to 3 times a day one hour before meals.

Maintenance dose: May increase every 1 to 2 weeks up to 50 mg orally three times a day. If blood pressure remains uncontrolled after 1 to 2 weeks at this dose, add a thiazide diuretic (loop diuretic if severe renal impairment exists) and titrate to its highest usual antihypertensive dose before further increases of captopril.
Maximum dose: 450 mg/day.

Congestive heart failure:

Initial dose: 25 mg orally three times a day (6.25 to 12.5 mg orally three times a day if hypotensive, hyponatremic, or hypovolemic).

Target maintenance dose: 50 mg orally three times a day for at least two weeks to ensure a satisfactory response.

Maximum dose: 450 mg/day.

Left ventricular dysfunction:

Initial dose: 6.25 mg orally once as early as three days post-myocardial infarction, followed by 12.5 mg orally three times a day; increase to 25 mg orally three times a day over the next several days, and then increase to target dose over the next several weeks as tolerated.

Target maintenance dose: 50 mg orally three times a day.

Diabetic nephropathy:

The recommended dose is 25 mg orally three times a day.

Hypertensive emergency:

25 mg orally 2 to 3 times a day; continue diuretic therapy and stop other antihypertensives upon initiation of this drug; may increase dose every 24 hours or less until satisfactory blood pressure or maximum dose is reached.

What is the dose of lopril (captopril) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is lopril (captopril) available?

Lopril is available in the following dosage forms and strengths:

  • Tablet 25mg, 50mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of lopril, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: February 10, 2017 | Last Modified: December 19, 2019

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