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What is Kefzol® (cefazolin) used for?

Cefazolin is a cephalosporin. It works by fighting bacteria in your body.

Kefzol® is commonly used for treat bacterial infections, including severe or life-threatening forms.

Kefzol® may also be used for purposes; ask your doctor for more information.

How should I take Kefzol® (cefazolin)?

Cefazolin is injected into a muscle or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, IV tubing, and other items used to inject the medicine.

Cefazolin must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Shake the mixture well just before you measure a dose. Do not use the medicine if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away).

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cefazolin will not treat a viral infection such as the flu or a common cold.

Cefazolin can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using cefazolin.

Store unmixed cefazolin dry powder at room temperature, away from moisture, heat, and light.

After mixing cefazolin with a diluent, you may store the mixture in the refrigerator and use it within 10 daysDo not freeze. Follow the storage directions on your medicine label.

You may store the mixture for up to 24 hours at room temperature.

How do I store Kefzol® (cefazolin)?

Kefzol® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Kefzol® in the bathroom or the freezer. There may be different brands of Kefzol® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Kefzol® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Kefzol® (cefazolin)?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredients of this drug.
  • You have ever had a severe allergic reaction to any type of cephalosporin antibiotic (Omnicef, Cefzil, Ceftin, Keflex, and others).
  • You are malnourished.
  • You are allergic to any type of penicillin.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Kefzol® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Kefzol®. Kefzol® is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


Cefazolin can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

Side effects

What side effects can occur from Kefzol® (cefazolin)?

When using this drug, common side effects may occur:

Call your doctor at once if you have:

  • Diarrhea (that is watery or bloody)
  • White patches or sores inside your mouth or on your lips
  • Fever
  • Swollen glands
  • Rash or itching
  • Joint pain
  • General ill feeling
  • Seizure (convulsions)
  • Liver problems such as upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • Severe skin reaction including sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash causing blistering and peeling

Get emergency medical help if you have signs of an allergic reaction such as hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Kefzol® (cefazolin)?

Kefzol® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

These products may include:

  • Cefaclor (Raniclor)
  • Cefadroxil (Duricef)
  • Cefdinir (Omnicef)
  • Cefazolin (Ancef)
  • Cefditoren (Spectracef)
  • Cefpodoxime (Vantin)
  • Cefprozil (Cefzil)
  • Ceftibuten (Cedax)
  • Cefuroxime (Ceftin)
  • Cephalexin (Keflex)
  • Cephradine (Velosef)

Does food or alcohol interact with Kefzol® (cefazolin)?

Kefzol® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Kefzol® (cefazolin)?

Kefzol® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

To make sure cefazolin is safe for you, tell your doctor if you have:

  • Kidney disease
  • Liver disease
  • A stomach or intestinal disorder such as colitis


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Kefzol® (cefazolin).

What is the dose of Kefzol® (cefazolin) for an adult?

Moderate-to-severe infections

The recommended dose is 0.5-1 g IV q6-8hr.

Mild infections with gram-positive cocci

The recommended dose is 250-500 mg IV q8hr.

Mild-to-moderate cholecystitis

The recommended dose is 1-2 g IV q8hr for 4-7 days.

Uncomplicated urinary tract infection

The recommended dose is 1 g IV q12hr.

Prophylaxis against infection

Preoperatively: The recommended dose is 1-2 g IV/IM ≤60 minutes before the procedure (may be repeated for 2-5 hours intraoperatively).

Postoperatively: The recommended dose is 0.5-1 g IV q6-8hr for 24 hours.

Surgical infection

Cardiac procedures, hysterectomy, oral or pharyngeal procedures, craniotomy, joint replacement, thoracic procedures, arterial procedures, amputation, traumatic wounds; high-risk esophageal, gastroduodenal, or biliary tract procedures: The recommended dose is 1-2 g IV.

Colorectal procedures: The recommended dose is 1-2 g IV plus metronidazole 0.5 g IV.

High-risk cesarean section, 2nd trimester abortion: The recommended dose is 1 g IV.

Ophthalmic procedures: The recommended dose is 100 mg subconjunctivally.


The recommended dose is 1 g IV/IM 30-60 minutes before procedure.

Bacterial Keratitis (Off-label)

The recommended dose is 1 drop instilled into affected eye(s) q1-2hr; typically alternated every other hour with antibiotic providing gram-negative coverage (e.g., tobramycin).

Renal impairment

CrCl 35-54 ml/min: Give full dose at intervals >8hr.

CrCl 10-35 ml/min: Give therapeutic dose q12hr.

CrCl ≤10 ml/min: Give therapeutic dose q24hr.

What is the dose of Kefzol® (cefazolin) for a child?

Infections with gram-positive cocci

Neonates (<28 days)

  • <7 days: The recommended dose is 40 mg/kg/day IV/IM divided q12hr.
  • >7 days, <2 kg: The recommended dose is 40 mg/kg/day IV/IM divided q12hr.
  • >7 days, >2 kg: The recommended dose is 60 mg/kg/day IV/IM divided q8hr.

Infants & children

  • The recommended dose is 25-100 mg/kg/day IV/IM divided q6-8hr; not to exceed 6 g/day.


The recommended dose is 50 mg/kg IV/IM ≤30-60 minutes before procedure; not to exceed 1 g.

Community-Acquired Pneumonia

>3 months and children: The recommended dose is 150 mg/kg/day IV/IM divided q8hr.

How is Kefzol® (cefazolin) available?

Kefzol® is available in the following dosage forms and strengths:

  • Kefzol® injection, cefazoline sodium 1g

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Kefzol®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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