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What is Janumet® (Sitagliptin, Metformin) used for?

Janumet® is commonly used for helping lower blood sugar in adults with type 2 diabetes by:

  • Helps your pancreas make more insulin.
  • Helps your body use the insulin more effectively that it makes.
  • Helps decrease excess sugar that your liver makes.

Important limitations of use:

  • Janumet® should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
  • Janumet® has not been studied in patients with a history of pancreatitis.

Janumet® may be prescribed for other uses. Ask your doctor or pharmacist for more information.

How should I take Janumet® (Sitagliptin, Metformin)?

  • Take Janumet® with meals to lower your chance of having an upset stomach.
  • Swallow Janumet® tablets whole. Do not break or cut tablets before swallowing.
  • Ask your health care provider any questions you may have about how to use

How do I store Janumet® (Sitagliptin, Metformin)?

Janumet® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Janumet® in the bathroom or the freezer. There may be different brands of Janumet® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Janumet® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Janumet® (Sitagliptin, Metformin)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Janumet® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You are going to get an injection of dye or contrast agents for an X-ray procedure. You will need to temporarily stop taking Janumet®.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Janumet® (Sitagliptin, Metformin)?

Janumet® may cause these side effects, such as:

  • Mild symptoms of lactic acidosis, includingmuscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or irregular heart rate, dizziness, or feeling very weak or tired.
  • Signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
  • Pancreatitis – severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate.
  • Urinating less than usual or not at all.
  • Feeling short of breath (even with mild exertion) swelling or rapid weight gain.
  • Severe skin reaction, fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Janumet® (Sitagliptin, Metformin)?

Janumet® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

These medications may affect Sitagliptin and Metformin:

  • Acetazolamide (Diamox);
  • Cimetidine (Tagamet), ranitidine (Zantac);
  • Morphine (MS Contin, Kadian, Oramorph);
  • Ranitidine (Zantac);
  • Topiramate (Topamax);
  • Trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra) or vancomycin (Vancocin, Lyphocin);
  • Glipizide (Glucotrol, Metaglip), glimepiride (Amaryl, Avandaryl, Duetact), glyburide (DiaBeta, Micronase, Glucovance);
  • Heart or blood pressure medications such as amiloride (Midamor), digoxin (Lanoxin), furosemide (Lasix), nifedipine (Nifedical, Procardia), procainamide (Procan, Pronestyl, Procanbid), quinidine (Quin-G), triamterene (Dyrenium).

If you have problems with high blood sugar, taking Janumet® with other drugs could affect your condition, such as:

  • Isoniazid;
  • Diuretics (water pills);
  • Steroids (prednisone and others);
  • Heart or blood pressure medication (Cartia, Cardizem, Covera, Isoptin, Verelan, and others);
  • Niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others);
  • Phenothiazines (Compazine and others);
  • Thyroid medicine (Synthroid and others);
  • Birth control pills and other hormones;
  • Seizure medicines (Dilantin and others);
  • Diet pills or medicines to treat asthma, colds or allergies.

Does food or alcohol interact with Janumet® (Sitagliptin, Metformin)?

Janumet® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Janumet® (Sitagliptin, Metformin)?

Janumet® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

  • Have or have had inflammation of your pancreas (pancreatitis).
  • Have kidney problems.
  • Have liver problems.
  • Have heart problems, including congestive heart failure.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Janumet® (Sitagliptin, Metformin) for an adult?

Individualize the starting dose of Janumet® based on the patient’s current regimen. May adjust the dosing based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin.

The recommended starting dose in patients not currently treated with metformin:

50 mg sitagliptin/500 mg metformin hydrochloride twice daily, with gradual dose escalation recommended to reduce gastrointestinal side effects associated with metformin.

The starting dose in patients already treated with metformin:

Sitagliptin dosed as 50 mg twice daily (100 mg total daily dose) and the dose of metformin already being taken.

For patients taking metformin 850 mg twice daily, the recommended starting dose of Janumet® is 50 mg sitagliptin/1000 mg metformin hydrochloride twice daily.

What is the dose of Janumet® (Sitagliptin, Metformin) for a child?

The dosage has not been established in pediatric patients (younger than 18 years old). It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Janumet® (Sitagliptin, Metformin) available?

Janumet® is available in the following dosage forms and strengths:

  • Janumet® film-coated tablets 50mg sitagliptin/500mg metformin.
  • Janumet® film-coated tablets 50mg sitagliptin/1000mg metformin.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

It is also important to carry a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking with you in case of emergencies.

What should I do if I miss a dose?

If you miss a dose of Janumet®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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