By Medically reviewed by Hello Doktor Medical Panel


What is histodil used for?

Histodil is commonly used for treating and preventing ulcers of the stomach and small intestine, and gastroesophageal reflux disease (GERD).

It may be used for treating esophagitis (inflammation of the esophagus) caused by acid reflux and certain conditions that cause increased acid secretion (e.g., Zollinger-Ellison syndrome).

It may also be used to treat other conditions as determined by your doctor.

How should I take histodil?

Use histodil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take histodil by mouth with or without food.

Do not take an antacid within 1 hour before or after you take histodil.

If you also take cephalosporin (e.g., cephalexin), itraconazole, or ketoconazole, take it at least 2 hours before taking histodil. Check with your doctor if you have questions.

How do I store histodil?

Histodil is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store histodil in the bathroom or the freezer. There may be different brands of histodil that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush histodil down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using histodil?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in histodil.
  • You are taking medicine for cancer (nitrosoureas).
  • You are taking cisapride, dofetilide, or a nitrosoureas (e.g., carmustine).

Also, there is some important safety information that you may notice:

  • Histodil may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use cimetidine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • It may be necessary to make significant lifestyle changes to assist in the treatment and prevention of ulcers and other digestive problems that include stress-reduction programs, exercise, and dietary changes.
  • If your symptoms do not get better within a few days, or if they get worse, check with your doctor.
  • Never self-diagnose or self-treat ulcers with this or any other medicine.
  • Notify your doctor if you experience black, tarry stools or vomit that looks like coffee grounds.
  • Do not drink alcohol while you are using histodil.
  • Do not smoke or use other tobacco products while using histodil.
  • Additional monitoring of your dose or condition may be necessary if you are also taking zaleplon.
  • Use cimetidine with caution in the elderly; they may be more sensitive to its effects.
  • Histodil should be used with extreme caution in children younger than 16 years old; safety and effectiveness have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using histodil during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking histodil. Histodil is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from histodil?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Diarrhea
  • Dizziness
  • Drowsiness
  • Headache

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Itching
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Agitation
  • Anxiety
  • Breast enlargement
  • Breast lumps
  • Confusion
  • Depression
  • Disorientation
  • Fatigue
  • Hallucinations
  • Hair loss
  • Joint or muscle pain
  • Pain, redness or swelling at injections site
  • Skin flushing or redness
  • Sexual difficulties
  • Slow or fast heartbeat

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with histodil?

Histodil may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Especially, if you are taking many prescription medicines (e.g., those used for angina, asthma, arrhythmias, blood thinning, cancer, erectile dysfunction, high blood pressure, infections, pain, psychiatric disorders, seizures, other conditions), because they may interact with histodil, increasing the risk of side effects, some potentially life-threatening.

Does food or alcohol interact with histodil?

Histodil may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with histodil?

Histodil may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have liver or kidney problems.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using histodil.

What is the dose of histodil for an adult?

Benign Gastric Ulcer

The recommended dose is 800 mg PO Qhs.

The recommended dose is 400 mg PO q12hr.

The recommended dose is 300 mg PO q6hr.

Duodenal Ulcer

The recommended dose is 800 mg PO Qhs.

The recommended dose is 400 mg PO q12hr.

The recommended dose is 300 mg PO q6hr.

Erosive Gastroesophageal Reflux Disease

The recommended dose is 800 mg PO q12hr.

The recommended dose is 400 mg PO q6hr.


(Over the counter only)

To relieve symptoms: The recommended dose is 200 mg PO up to q12hr.

To prevent symptoms: The recommended dose is 200 mg PO with glass of water right before or any time up to 30 minutes before eating food or drinking beverages that cause heartburn.

Pathological Hypersecretory Conditions

The recommended dose is 300 mg PO q6hr with meals and HS.

Renal Impairment

The recommended dose is CrCl<30 ml/min.

The recommended dose is 300 mg IV/IO q12hr.

Prevention of upper GI bleeding:

The recommended dose is 25 mg/hour continuous IV infusion.

What is the dose of histodil for a child?

Duodenal Ulcer (Off-label)

<16 years: Use only if benefit outweighs risks.

The recommended dose is 20-40 mg/kg/day IV/PO divided q6hr.

Neonates (<28 days old): The recommended dose is 5-20 mg/kg/day IV/PO divided q8-12hr.

Infants: The recommended dose is 10-20 mg/kg/day IV/PO divided q6-12hr.

How is histodil available?

Histodil is available in the following dosage forms and strengths:

  • Histodil 100mg/ml injection vial 2ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of histodil, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

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Review Date: April 1, 2017 | Last Modified: December 19, 2019

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