Gofen 400

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Kemas kini Tarikh 12/05/2020 . 5 minit bacaan
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What is Gofen 400® (ibuprofen) used for?

Gofen 400® is commonly used for treatment temporary relief of minor aches and pain associated with common colds, headache, toothache, muscular aches, backache, minor pain from arthritis, menstrual cramps (dysmenorrhea) and fever.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Gofen 400® (ibuprofen) .

What is the dose of Gofen 400® (ibuprofen) for an adult?

Take 1 capsule every 4-6 hours when symptoms occur.

The maximum daily dose for adults when administered oral is 2.4 g.

Rheumatoid arthritis – by 0.8 g 3 times a day in osteoarthrosis and ankylosing spondylitis – by 0.4-0.6 g 3-4 times a day,

What is the dose of Gofen 400® (ibuprofen) for a child?

Children over 12 years: take 1 capsule every 4-6 hours when symptoms occur.

Juvenile rheumatoid arthritis: 30-40 mg /kg /day in several stages.

But do not exceed 3 capsules in 24 hours unless directed by physician.


How should I take Gofen 400® (ibuprofen)?

Use ibuprofen exactly as directed on the label, or as prescribed by your doctor. Do not use in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Do not take more than your recommended dose. An ibuprofen overdose can damage your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount needed to get relief from your pain, swelling, or fever.

A child’s dose of ibuprofen is based on the age and weight of the child. Carefully follow the dosing instructions provided with your child’s medicine for the age and weight of your child. Ask a doctor or pharmacist if you have questions.

Take ibuprofen with food or milk into lessen stomach upset.

Read all patient information, Gofen 400® guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

What should I do in case of an emergency or overdose?

In case of overdose, call your local poison control center or emergency services.

Symptoms of overdose may include:

  • Dizziness;
  • Fast eye movements that you cannot control;
  • Slow breathing or short periods of time without breathing;
  • Blue color around the lips, mouth, and nose.

What should I do if I miss a dose?

If you miss a dose of Gofen 400®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Side effects

What side effects can occur from Gofen 400® (ibuprofen)?

  • Digestive system: frequently nausea, anorexia, vomiting, epigastric discomfort, diarrhea, possibly the development of erosive and ulcerative lesions of the gastrointestinal tract; rare bleeding from the gastrointestinal tract, long-term use possible liver problems.
  • Central nervous system and peripheral nervous systems: frequently headache, dizziness, sleep disturbances, agitation, visual impairment.
  • Hemopoietic system: long-term use may be anemia, thrombocytopenia, agranulocytosis.
  • Urinary tract: long-term use possible renal dysfunction.
  • Allergic reactions: often skin rash, Quincke’s edema, rarely aseptic meningitis (usually in patients with autoimmune diseases), bronchospasm syndrome.
  • Local reactions: when topical used may be hyperemia of the skin, burning or tingling.


What should I know before using Gofen 400® (ibuprofen)?

  • Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
  • Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using ibuprofen, especially in older adults.
  • You should not use ibuprofen if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
  • Precautions are used with the attendant liver and kidney diseases, chronic heart failure, with dyspeptic symptoms before treatment, immediately after surgery, with indications of a history of gastrointestinal bleeding in diseases of the digestive tract, allergic reactions associated with NSAID intake.
  • In the course of treatment requires systematic monitoring of the liver and kidneys, peripheral blood picture.
  • It should not be applied externally to the damaged skin.

Is it safe in specific conditions (e.g. pregnancy, breastfeeding, or surgery)?

Do not use ibuprofen in the third trimester of pregnancy. Application the first and second trimesters of pregnancy is justified only in cases which the expected benefit to the mother is higher than the possible harm to the fetus.

Gofen 400® in small amounts excretes in breast milk. Possible using in lactation for pain and fever. If necessary, prolonged use or use in high doses (800 mg / 24 h), should decide on the termination of breastfeeding.


What drugs may interact with Gofen 400® (ibuprofen)?

  • With simultaneous use of ibuprofen reduces the effect of antihypertensive agents (ACE inhibitors, beta-blockers), diuretics (furosemide, hypothiazide).
  • With the simultaneous use of anticoagulants may enhance their action.
  • With simultaneous application of SCS increases the risk of side effects from the gastrointestinal tract.
  • With the simultaneous application of ibuprofen may displace from compounds with plasma proteins indirect anticoagulants (acenocoumarol), derivatives of hydantoin (phenytoin), oral hypoglycemic drugs sulfonylurea derivatives.
  • With the simultaneous use of amlodipine may be a slight reduction of antihypertensive action of amlodipine, with acetylsalicylic acid – decreased concentration of ibuprofen in blood plasma, with baclofen – described a case of toxic gain of baclofen.
  • When applied simultaneously with warfarin may increase bleeding time, were also observed microhematuria, bruises with hydrochlorothiazide – perhaps a slight reduction of antihypertensive action of hydrochlorothiazide, captopril – may reduce antihypertensive effect of captopril, with cholestyramine – moderately decrease absorption of ibuprofen.
  • With simultaneous application of lithium carbonate increased the concentration of lithium in blood plasma.
  • With simultaneous application of magnesium hydroxide increases the initial absorption of ibuprofen, with methotrexate – increases the toxicity of methotrexate.
  • Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.

Does food or alcohol interact with Gofen 400® (ibuprofen)?

Ask your doctor before using ibuprofen together with ethanol. Do not drink alcohol while taking ibuprofen, alcohol can increase your risk of stomach bleeding. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other Gofen 400®s you use, including vitamins and herbs. Do not stop using any Gofen 400®s without first talking to your doctor.

How do I store Gofen 400® (ibuprofen)?

Gofen 400® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Gofen 400® in the bathroom or the freezer. There may be different brands of Gofen 400® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Gofen 400® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

How is Gofen 400® (ibuprofen) available?

Gofen 400® is available in the following dosage forms and strengths:

  • Soft gel capsule 400 mg.

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