Diamicron MR

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Kemas kini Tarikh 12/05/2020 . 5 minit bacaan
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What is Diamicron MR® (gliclazide) used for?

Diamicron MR® is commonly used to control blood glucose in people with type 2 diabetes. It is used when diet, exercise, and weight reduction have not been found to control blood glucose well enough. Gliclazide increases the amount of insulin released by the pancreas and helps the body use insulin more efficiently.

How should I take Diamicron MR® (gliclazide)?

Gliclazide should be taken with meals if possible. Swallow the tablet whole and do not chew or crush.

How do I store Diamicron MR® (gliclazide)?

Diamicron MR® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Diamicron MR® in the bathroom or the freezer. There may be different brands of Diamicron MR® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Diamicron MR® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Diamicron MR® (gliclazide)?

Before you begin taking Diamicron MR®, be sure to inform your doctor of any medical conditions or allergies you may have, any ingredients of Diamicron MR® you are taking, whether you are pregnant or breastfeeding, and any other significant facts about your health.

Do not take gliclazide if you:

  • Are allergic to other sulfonylureas (such as glyburide) or sulfonamides (such as sulfamethoxazole)
  • Are taking some forms of miconazole
  • Are experiencing physical stress such as serious infection, injury or surgery
  • Have severe kidney or liver disease
  • Have type 1 diabetes
  • Have unstable diabetes or ketoacidosis (a high amount of ketones in your urine)

Is it safe during pregnancy or breastfeeding?


There are no adequate studies in women for determining risk when using Diamicron MR® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Diamicron MR®. Diamicron MR® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


It is not known if gliclazide passes into breast milk. If you are a breastfeeding mother and are taking Diamicron MR®, it may affect your baby. Breastfeeding women should not take gliclazide.

Side effects

What side effects can occur from Diamicron MR® (gliclazide)?

Check with your doctor as soon as possible if any of the following side effects occur:

  • High blood pressure
  • Signs of anemia such as dizziness, pale skin, unusual tiredness or weakness, shortness of breath
  • Signs of clotting problems such as unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums
  • Signs of depression including poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide
  • Signs of liver problems such as nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools
  • Skin rash
  • Hives
  • Swelling of the legs
  • Unexpected weight gain
  • Symptoms of low blood sugar including cold sweat, cool pale skin, headache, fast heartbeat, weakness, shakiness, feeling drunk, headache, slurred speech
  • Unusual or more frequent infections including fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness

Stop taking the Diamicron MR® and seek immediate medical attention if any of the following occur:

  • Chest pain or pressure and/or shortness of breath
  • Seizures
  • Signs of a serious allergic reaction such as abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat
  • Signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
  • Unconsciousness

Some people may experience side effects which is not listed above. Check with your doctor if you notice any symptom that worries you while you are taking Diamicron MR®.


What drugs may interact with Diamicron MR® (gliclazide)?

Diamicron MR® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Diamicron MR® (gliclazide)?

Diamicron MR® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Diamicron MR® (gliclazide)?

Diamicron MR® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions could affect your medication:

  • Diabetes complications
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • Hypoglycemia (low blood sugar)
  • Illness/stress
  • Kidney function
  • Liver function
  • Proper diet
  • Worsening of condition


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Diamicron MR®.

What is the dose of Diamicron MR® (gliclazide) for an adult?

The recommended starting dose of gliclazide is 30 mg taken once daily at the same time every day. Your doctor will gradually increase the dose every two weeks to a maximum of 120 mg daily, depending on the reduction of your blood glucose.

It is recommended that Diamicron MR® be taken at breakfast time.

What is the dose of Diamicron MR® (gliclazide) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Diamicron MR® (gliclazide) available?

Diamicron MR® is available in the following dosage forms and strengths:

  • Tablet 30mg
  • Tablet 60mg
  • Tablet 80mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Diamicron MR®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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