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Kemas kini Tarikh 12/05/2020 . 6 minit bacaan
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What is Aspegic® (Acetylsalicylic acid – ASA) used for?

Aspegic® is commonly used for relieving pain, fever, and inflammation in various conditions such as lower back and neck pain, the flu, common cold, burns, menstrual pain, headache, migraines, osteoarthritis, rheumatoid arthritis, sprains and strains, nerve pain, toothache, muscle pain, bursitis (inflammation of a bursa, a fluid-filled sac located around joints and near the bones), and following surgical and dental procedures. ASA is also used for rheumatic fever in combination with other medications. In these situations, ASA is used on an as-needed basis.

Because of the antiplatelet properties of ASA, it may be used under the supervision of your doctor to:

  • Prevent a first nonfatal heart attack in people who are at increased risk of having a heart attack as determined by their doctor.
  • Prevent a second heart attack or stroke.
  • Reduce the risk of “mini-stroke” or transient ischemic attack (TIA).
  • Reduce the clotting properties of platelets for people who have had carotid artery surgery to prevent the recurrence of TIA and for people receiving hemodialysis through a silicone rubber access.
  • Prevent blood clots for people who have had a total hip replacement.

How should I take Aspegic® (Acetylsalicylic acid – ASA)?

The oral administration dosing regimen depends on indication for use.

Use Aspegic® exactly as prescribed by your doctor. Do not use this medicine in larger or smaller amounts or for longer than recommended.

How do I store Aspegic® (Acetylsalicylic acid – ASA)?

Aspegic® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Aspegic® in the bathroom or the freezer. There may be different brands of Aspegic® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Aspegic® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.


Precautions & warnings

What should I know before using Aspegic® (Acetylsalicylic acid – ASA)?

  • Using caution in patients with liver diseases and kidney, bronchial asthma, erosive and ulcerative lesions, and bleeding from the digestive tract in history, with increased bleeding or while holding anticoagulant therapy, decompensated congestive heart failure.
  • Acetylsalicylic acid even in small doses reduces the excretion of uric acid from the organism that can cause an acute attack of gout in predisposed patients. When conducting long-term therapy and / or use of aspirin in high doses required medical supervision and regular monitoring of hemoglobin levels.
  • The use of acetylsalicylic acid as anti-inflammatory drugs in a daily dose of 5-8 g is limited due to the high probability of adverse effects from the gastrointestinal tract.
  • Before surgery, to reduce bleeding during surgery and postoperative period, patients should stop taking salicylates for 5-7 days.
  • During prolonged therapy, it is necessary to conduct a general analysis of blood and study of occult blood.

Is it safe during pregnancy or breastfeeding?


Aspegic® is contraindicated in I and III trimester of pregnancy. In pregnancy trimester II, it can be the one-off reception on the strict condition.

This medication has a teratogenic effect. When drug is used in the I trimester leading to top palatoschisis, in the III trimester causing inhibition of labor (inhibition of prostaglandin synthesis), premature closure of the ductus arteriosus in the fetus, pulmonary vascular hyperplasia and hypertension in the pulmonary circulation.


Aspegic® is excreted in breast milk, which increases the risk of bleeding in a child due to dysfunction of platelets, and therefore should not be applied acetylsalicylic acid in the mother during lactation.

Side effects

What side effects can occur from Aspegic® (Acetylsalicylic acid – ASA)?

If you notice any of the following side effects, call your doctor for more information.

  • Digestive system includes nausea, vomiting, anorexia, epigastric pain, diarrhea, occurrence of erosive and ulcerative lesions (rarely), bleeding from the gastrointestinal tract, abnormal liver function.
  • Central nervous system when long-term using may cause dizziness, headache, reversible visual disturbances, tinnitus, aseptic meningitis.
  • Hemopoietic system includes thrombocytopenia (rarely), anemia.
  • Blood coagulation system includes hemorrhagic syndrome (rarely), prolongation of bleeding time.
  • Urinary system: renal dysfunction (rarely), acute kidney failure (with prolonged using), nephrotic syndrome.
  • Allergic reactions include skin rash (rarely), Quincke’s edema, bronchospasm, “aspirin triad” (a combination of bronchial asthma, recurrent nasal polyposis, and paranasal sinuses and intolerance of acetylsalicylic acid and medicines pirazolonic series).
  • In some cases, it happens Reye syndrome, increased symptoms of chronic heart failure (long-term using).


What drugs may interact with Aspegic® (Acetylsalicylic acid – ASA)?

Aspegic® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug when using simultaneous, including:

  • Antacids containing magnesium and / or aluminum hydroxide slow down and reduce the absorption of acetylsalicylic acid.
  • Calcium channel blockers, means limiting intake of calcium or increasing the excretion of calcium from the body, increases the risk of bleeding.
  • Acetylsalicylic acid enhances the action of heparin and indirect anticoagulants, hypoglycemic funds derived sulfonylureas, insulin, methotrexate, phenytoin, valproic acid.
  • SCS increases the risk of ulcerogenic effect and occurrence of gastrointestinal bleeding.
  • Diuretics (spironolactone, furosemide) decrease the effectiveness.
  • NSAIDs increases the risk of side effects. Acetylsalicylic acid may reduce plasma concentrations indomethacin, piroxicam.
  • Uricosuric medications (including probenecid, sulfinpirazon, benzbromarone) decreases the effectiveness.
  • Acetylsalicylic acid and alendronate sodium may develop severe esophagitis.
  • Griseofulvin may be in breach absorption of acetylsalicylic acid.
  • Ginkgo Biloba occurs spontaneous hemorrhage in the iris.
  • Dipyridamole may increase Cmax of salicylate in plasma and AUC.
  • Acetylsalicylic acid increased concentration of digoxin, barbiturates and lithium salts in the blood plasma.
  • Salicylates in high doses with carbonic anhydrase inhibitors can intoxication salicylates.
  • Caffeine increases the rate of absorption, plasma concentrations and bioavailability of acetylsalicylic acid.
  • Metoprolol may increase Cmax of salicylate in blood plasma.
  • Pentazocine gets a risk of severe adverse reactions in the kidneys.
  • phenylbutazone reduces uricosuria caused by acetylsalicylic acid.
  • Ethanol may exacerbate the effects of acetylsalicylic acid on the gastrointestinal tract.

Does food or alcohol interact with Aspegic® (Acetylsalicylic acid – ASA)?

Aspegic® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Aspegic® (Acetylsalicylic acid – ASA)?

Aspegic® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Aspegic® (Acetylsalicylic acid – ASA).

What is the dose of Aspegic® (Acetylsalicylic acid – ASA) for an adult?

Antipyretic and analgesic

500-1000 mg / day (up to 3 g) were divided into 3 admissions.

Myocardial infarction

40-325 mg 1 time a day (usually 160 mg).

An inhibitor of platelet aggregation

300-325 mg / day, for a long time.

The dynamic circulatory disorders in men, cerebral thromboembolism

325 mg / day with gradual increase to a maximum of 1 g / day.

Thrombosis or occlusion of the aortic shunt

325 mg every 7 h after intranasal gastric tube set, and then through the mouth to 325 mg 3 times a day.

What is the dose of Aspegic® (Acetylsalicylic acid – ASA) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Aspegic® (Acetylsalicylic acid – ASA) available?

Aspegic® is available in the following dosage forms and strengths:

  • Injectable; Injection: 1000 mg
  • Injectable; Injection: 500 mg
  • Powder for Solution; Oral: 100 mg
  • Powder for Solution; Oral: 1000 mg
  • Powder for Solution; Oral: 250 mg
  • Powder for Solution; Oral: 500 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Aspegic®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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