Apo Piroxicam

By Medically reviewed by Hello Doktor Medical Panel


What is apo piroxicam used for?

Apo piroxicam is commonly used for relieving the symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis (a condition associated with inflammation of the joints in the spine and between the spine and pelvis).

Piroxicam also relieves pain and reduces swelling, inflammation by reducing a substance in the body that leads to inflammation and pain.

How should I take apo piroxicam?

Take this medication immediately after food, or with food or milk to avoid stomach upset. Do not crush or chew.

How do I store apo piroxicam?

Apo piroxicam is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store apo piroxicam in the bathroom or the freezer. There may be different brands of apo piroxicam that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush apo piroxicam down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using apo piroxicam?

Before using this drug, tell your doctor if you:

  • Have allergic to piroxicam or any ingredients of this medication.
  • Are allergic to ASA or other NSAIDs (e.g., ibuprofen, ketorolac, diclofenac).
  • Have had allergic symptoms (e.g., runny nose; asthma; itchy skin rash; nasal polyps; swelling of the face, throat or tongue) caused by these medications.
  • Are breastfeeding.
  • Are in the third trimester (last 3 months) of pregnancy.
  • Have a bleeding disorder.
  • Have an inflammatory bowel disease (e.g., ulcerative colitis, Crohn’s disease).
  • Have an ulcer or bleeding in the stomach or intestines.
  • Have bleeding in the brain.
  • Have had recent or are going to have heart bypass surgery.
  • Have high blood potassium.
  • Have liver disease or severely reduced liver function.
  • Have severe uncontrolled heart failure.
  • Have severely reduced or worsening kidney function.

Do not use the suppository form of this medication if you have inflammation or recent bleeding from the anus or rectum.

Is it safe during pregnancy or breastfeeding?


This medication should not be used during pregnancy, especially during the third trimester. If you become pregnant while taking this medication, contact your doctor immediately.

This medication may reduce fertility. If you are trying to get pregnant or are having difficulty getting pregnant, you should not use this medication.


Piroxicam passes into breast milk. If you are a breastfeeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.

Side effects

What side effects can occur from apo piroxicam?

These common side effects may include:

  • Abdominal or stomach cramps, pain, or discomfort (mild to moderate)
  • Drowsiness
  • Fatigue
  • Heartburn or indigestion
  • Nausea
  • Sun sensitivity

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention. Check with your doctor as soon as possible if any of the following side effects occur:

  • Signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
  • Signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
  • Increased sensitivity of skin to sunlight
  • Rectal irritation (with suppositories)
  • Signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • Skin rash
  • Sores or ulcers in mouth
  • Swelling of feet, lower legs, arms, and hands
  • Urinating problems (e.g., bladder pain, painful urination, frequent urination)
  • Vomiting or persistent nausea, stomach pain, or diarrhea
  • Bleeding from rectum (with suppositories)
  • Confusion
  • Difficulty hearing
  • Dizziness or lightheadedness
  • Flu-like symptoms (e.g., achiness, chills, fever)
  • Headache and stiff neck
  • Heartburn (persistent)

Stop taking the medication and seek immediate medical attention if any of the followings occur:

  • Blurred vision or any visual disturbance
  • Change in the amount or color of urine
  • Signs of aseptic meningitis (e.g., stiff neck, severe headache, nausea, vomiting, fever, or changes in consciousness)
  • Signs of bleeding in the stomach (e.g., bloody, black, or  tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
  • Signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
  • Signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
  • Signs of stroke (e.g., sudden or a severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
  • Severe allergic reaction (e.g., hives; difficulty breathing; swelling of the face, mouth, throat or tongue)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with apo piroxicam?

Apo piroxicam may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with apo piroxicam?

Apo piroxicam may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with apo piroxicam?

Apo piroxicam may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions may affect how you should use this medication.

  • Aseptic meningitis
  • Bladder problems
  • Blood clotting
  • Blood counts
  • Drowsiness/reduced alertness
  • Fluid and electrolyte balance
  • Heart attack and stroke
  • Kidney function
  • Liver function
  • Skin reactions
  • Ulcers or bleeding in the stomach or intestines


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using apo piroxicam.

What is the dose of apo piroxicam for an adult?

The recommended dose of piroxicam ranges from 10 mg to 20 mg daily, depending on needs and circumstances.

A dose of 20 mg can be taken as either 20 mg once daily or 10 mg twice daily.

The usual maximum daily dose is 20 mg.

Piroxicam suppositories are also an alternative. The lowest dose needed for the shortest possible duration of treatment should be used.

What is the dose of apo piroxicam for a child?

The dosage has not been established for children less than 16 years old. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is apo piroxicam available?

Apo piroxicam is available in the following dosage forms and strengths:

  • Capsule 10mg
  • Capsule 20mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose and are taking piroxicam once a day, take it within 8 hours of your usual dose time and continue with your regular schedule.

If you have missed your dose by more than 8 hours, skip the missed dose and continue with your regular dosing schedule.

If you miss a dose and are taking piroxicam twice a day, take it within 2 hours of your usual dose time and continue with your regular schedule.

If you have missed your dose by more than 2 hours, skip the missed dose and continue with your regular dosing schedule.

Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Hello Health Group does not provide medical advice, diagnosis or treatment.

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Review Date: March 18, 2017 | Last Modified: December 19, 2019

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