Apo Amilzide


Kemas kini Tarikh 12/05/2020 . 5 minit bacaan
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What is Apo-Amilzide (amiloride/hydrochlorothiazide) used for?

Apo-Amilzide is commonly used to decrease edema that occurs with congestive heart failure and certain liver disorders. It is also used to treat hypertension.

How should I take Apo-Amilzide (amiloride/hydrochlorothiazide)?

To take this drug, you should:

  • Take this product by mouth as directed. Follow all directions on the product package.
  • If you are uncertain about any of the information, consult your doctor or pharmacist.

How do I store Apo-Amilzide (amiloride/hydrochlorothiazide)?

Apo-Amilzide is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Apo-Amilzide in the bathroom or the freezer. There may be different brands of Apo-Amilzide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Apo-Amilzide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Apo-Amilzide (amiloride/hydrochlorothiazide)?

Before using this drug, tell your doctor:

  • If you are allergic to amiloride, hydrochlorothiazide, sulfonamide containing medications, any other medications, or any of the ingredients in amiloride and hydrochlorothiazide tablets.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking amiloride and hydrochlorothiazide.

You should know that:

  • Amiloride and hydrochlorothiazide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking amiloride and hydrochlorothiazide. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Alcohol can add to these side effects.
  • If your doctor prescribes a low-salt or low-sodium diet, or to eat or drink increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet, follow these instructions carefully.

Is it safe during pregnancy or breastfeeding?


There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Apo-Amilzide (amiloride/hydrochlorothiazide)?

This drug may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

If you experience any of these symptoms, call your doctor immediately or seek emergency medical treatment:

  • Dry mouth
  • Thirst
  • Nausea
  • Vomiting
  • Weakness, tiredness
  • Drowsiness
  • Restlessness
  • Confusion
  • Muscle weakness, pain, or cramps
  • Fast heartbeat and other signs of dehydration and electrolyte imbalance
  • Slow or irregular heartbeat
  • Unusual bleeding or bruising
  • Yellowing of the skin or eyes
  • Rash
  • Hives
  • Itching
  • Difficulty breathing or swallowing

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Apo-Amilzide (amiloride/hydrochlorothiazide)?

Apo-Amilzide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Diazoxide
  • Digitalis glycosides
  • Loop diuretics (e.g., furosemide)
  • Sulfonylureas (e.g., chlorpropamide)
  • Spironolactone (Aldactone, in Aldactazide), other medications containing triamterene, or potassium supplements or potassium-containing medication supplements
  • Angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic), ramipril (Altace), and trandolapril (Mavik, in Tarka)
  • Angiotensin II receptor antagonists (ARB) such as azilsartan (Edarbi, Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten, in Teveten HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, Benicar HCT), telmisartan (Micardis, in Micardis HCT), and valsartan (Diovan, in Diovan HCT, Exforge)
  • Barbiturates such as phenobarbital and secobarbital (Seconal)
  • Corticosteroids such as betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, others), fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol), prednisolone (Prelone, others), prednisone (Rayos), and triamcinolone (Aristocort, Azmacort); corticotropin (ACTH H.P., Acthar Gel)
  • Cyclosporine (Gengraf, Neoral, Sandimmune)
  • Digoxin (Lanoxin)
  • Insulin and oral medications for diabetes
  • Lithium (Lithobid);
  • Medications for high blood pressure
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others), indomethacin (Indocin), and naproxen (Aleve, Naprosyn, others)
  • Tacrolimus (Astagraf XL, Prograf)

Does food or alcohol interact with Apo-Amilzide (amiloride/hydrochlorothiazide)?

Apo-Amilzide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Apo-Amilzide (amiloride/hydrochlorothiazide)?

Apo-Amilzide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Hyperkalemia
  • Kidney disease
  • Diabetes
  • Gout
  • Liver disease


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Apo-Amilzide (amiloride/hydrochlorothiazide).

What is the dose of Apo-Amilzide (amiloride/hydrochlorothiazide) for an adult?

The recommended dose is 1 to 2 tablets (5 mg amiloride/50 mg hydrochlorothiazide) daily with meals.

What is the dose of Apo-Amilzide (amiloride/hydrochlorothiazide) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Apo-Amilzide (amiloride/hydrochlorothiazide) available?

Apo-Amilzide is available in the following dosage forms and strengths:

  • Tablet 55mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

Symptoms of overdose include:

  • Dehydration
  • Electrolyte imbalance (e.g., hyperkalemia)
  • Electrolyte depletion (hypokalemia, hypochloremia, hyponatremia)

What should I do if I miss a dose?

If you miss a dose of Apo-Amilzide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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