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What is thiamphenicol used for?

Thiamphenicol is commonly used for treating typhoid fever, paratyphoid fever, and bacteria (Salmonella sp), other severe infections (H. influenza), meningitis (N. meningitides or S. pneumonia), urogenital infections including gonorrhea, etc.

How should I take thiamphenicol?

It comes as a tablet to take by mouth, with or without food.

How do I store thiamphenicol?

Thiamphenicol is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store thiamphenicol in the bathroom or the freezer. There may be different brands of thiamphenicol that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush thiamphenicol down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using thiamphenicol?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with thiamphenicol or other medications.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using thiamphenicol during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. Thiamphenicol is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk;
  • B=No risk in some studies;
  • C=There may be some risk;
  • D=Positive evidence of risk;
  • X=Contraindicated;
  • N=Unknown.

Side effects

What side effects can occur from thiamphenicol?

Thiamphenicol may cause these side effects such as:

  • Hypersensitivity;
  • GI disturbances;
  • Stomatitis;
  • Glossitis;
  • Encephalopathy;
  • Mental depression and headache;
  • Ototoxicity;
  • Haemolytic anemia (Mediterranean form of G6PD);
  • Jarish-Herxheimer reaction.
  • Prolonged use may induce bleeding, peripheral, and optic neuritis.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with thiamphenicol?

Thiamphenicol may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Thiamphenicol may change the effects of tolbutamide, phenytoin, dicoumarol, and other drugs that metabolized in the liver.

Does food or alcohol interact with thiamphenicol?

Thiamphenicol may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with thiamphenicol?

Thiamphenicol may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Hypersensitivity;
  • Preexisting bone marrow depression;
  • Blood dyscrasias;
  • Active immunization;
  • Patients with severe liver or renal impairment.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of thiamphenicol for an adult?

Sexually transmitted diseases, Susceptible infections

1.5 g daily in divided doses, up to 3 g/day initially for severe infections.


2.5 g/day for 1-2 days.

Alternatively, 2.5 g on the 1st day followed by 2 g/day on each of 4 subsequent days.

What is the dose of thiamphenicol for a child?

Susceptible infections

30-100 mg/kg/day.

How is thiamphenicol available?

Thiamphenicol is available in the following dosage forms and strengths:

  • Capsule 250mg; 500 mg;
  • Tablet 1g;
  • Suspension.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of medication, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

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