The correlation between gut bacteria and joint pain is not limited to osteoarthritis only. Rheumatoid arthritis is also discovered to be potentially linked to gut bacteria. A particular bacterium, Prevotella copri, was found in 75% of people with new, untreated rheumatoid arthritis, but only 21% of those without the disease. Once treated with anti-rheumatoid arthritis drugs, the bacterium virtually disappeared. Only one person in ten still had Prevotella copri in their gastrointestinal tract after treatment.
Can we prevent the inflammation?
Interestingly, the inclusion of prebiotic called oligofructose in the osteoarthritis research shows a different outcome. It seems to promote the growth of healthy bacteria and produced a marked reduction in pro-inflammatory bacteria in the mice. Prebiotics (not probiotics) cannot be broken down by mouse or human guts but act as a fertilizer that helps many beneficial bacteria to thrive.
Importantly, it also reduced inflammation in the joints, and the knee cartilage of the obese mice was the same as that of the non-obese control mice. The joints remain healthy although the mice gain excess weight. This also shows that osteoarthritis is mainly due to inflammation induced by obesity, not merely due to weight exertion.
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