Psoriasis is a chronic autoimmune condition characterised by the presence of patches of abnormal skin that are scaly, elevated and itchy. In darker people, the colour of the skin patches may be purple instead of pink. Psoriasis was initially thought to be primarily a disease of dysfunctional proliferation and differentiation of keratinocytes (the layer of cells that proliferates to form the surface of the skin). However, it is now widely recognised that additional roles are being played by T helper (Th)1 and Th17 lymphocytes in the formation of the disease, through the release of inflammatory cytokines that promotes further recruitment of immune cells, keratinocyte proliferation, and sustained chronic inflammation. Beyond the physical dimensions of the disease, psoriasis has an extensive emotional and psychosocial effect on patients, affecting social functioning and interpersonal relationships. As a disease of systemic inflammation, psoriasis is associated with multiple comorbidities, including cardiovascular disease and malignancy. This article will discuss the current management of Psoriasis that is divided into two – topical agents and systemic therapy.
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