What is Dalfampridine used for?
Dalfampridine is used to improve walking in people with multiple sclerosis (MS). It is a potassium channel blocker. It is thought to work by improving nerve conduction.
How should I take Dalfampridine?
Take this medication by mouth with or without food as directed by your doctor, usually twice a day. Swallow this medication whole. Do not crush, chew, or break this medication. Doing so can release all of the drug at once, increasing the risk of side effects. If you cannot swallow the tablets whole, talk with your doctor.
Dosage is based on your medical condition and response to treatment. To reduce the risks of side effects (such as seizures), do not take more medication or take it more frequently than prescribed. Your condition will not improve any faster and your risks of side effects will increase. Do not take more than 2 doses in a day. Take each dose 12 hours apart.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
Tell your doctor if your condition persists or worsens.
How do I store Dalfampridine?
Dalfampridine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Dalfampridine in the bathroom or the freezer. There may be different brands of Dalfampridine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.
You should not flush Dalfampridine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.
Precautions & warnings
What should I know before using Dalfampridine?
Before taking dalfampridine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, seizures.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this medication passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding.
Is it safe during pregnancy or breast-feeding?
There are no adequate studies in women for determining risk when using this Dalfampridine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Dalfampridine. Dalfampridine is pregnancy risk category C according to the US Food and Drug Administration (FDA).
FDA pregnancy risk category reference below:
- A=No risk,
- B=No risk in some studies,
- C=There may be some risk,
- D=Positive evidence of risk,
What side effects can occur from Dalfampridine?
Trouble sleeping (insomnia), dizziness, nausea, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Tell your doctor right away if you have any serious side effects, including: frequent/burning/painful urination, back pain, pink/bloody urine, new/worsening balance problems.
Get medical help right away if you have any very serious side effects, including: mental/mood changes (such as severe confusion, memory problems), seizure.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
What drugs may interact with Dalfampridine?
Dalfampridine may interact with acetaminophen-tramadol, bupropion, bupropion-naltrexone, iohexol, iopamidol, metrizamide, tramadol, among others.
Dalfampridine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Does food or alcohol interact with Dalfampridine?
Dalfampridine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
What health conditions may interact with Dalfampridine?
Dalfampridine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
Dalfampridine may interact with renal impairment and seizures.
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Dalfampridine.
What is the dose of Dalfampridine for an adult?
Usual Adult Dose for Multiple Sclerosis
Maximum dose: 10 mg orally every 12 hours
Renal Dose Adjustments
-Mild renal impairment (CrCl 51 to 80 mL/min): Plasma levels of this drug may approach those seen at a dose of 15 mg 2 times a day, a dose that is 1.5 times the maximum recommended dose and may be associated with an increased risk of seizures; because renal impairment is common after age 50, estimating CrCl is particularly important in these patients
-Moderate to severe renal impairment (CrCl less than 51 mL/min): Contraindicated
What is the dose of Dalfampridine for a child?
The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.
How is Dalfampridine available?
Dalfampridine is available in the following dosage forms and strengths:
- Oral tablet, extended release.
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
What should I do if I miss a dose?
If you miss a dose of Dalfampridine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
Review Date: November 20, 2018 | Last Modified: November 29, 2019
Dalfampridine Dosage. https://www.drugs.com/dosage/dalfampridine.html. Accessed November 20, 2018.
Dalfampridine ER. https://www.webmd.com/drugs/2/drug-153645/dalfampridine-oral/details. Accessed November 20, 2018.