Generic Name: Ziprasidone Brand Name(s): Ziprasidone.

Uses

What is ziprasidone used for?

Ziprasidone is an antipsychotic medication. It works by changing the effects of chemicals in the brain.

Ziprasidone is used to treat schizophrenia and the manic symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Ziprasidone may also be used for purposes not listed in this medication guide.

How should I take ziprasidone?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with food. Swallow the capsule whole.

While using ziprasidone, you may need frequent blood tests. Your kidney or liver function may also need to be checked.

If you are diabetic, check your blood sugar levels on a regular basis while you are taking ziprasidone.

Use ziprasidone regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

It may take several weeks before your symptoms improve. Do not stop using ziprasidone suddenly, even if you feel fine. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

How do I store ziprasidone?

Ziprasidone is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store ziprasidone in the bathroom or the freezer. There may be different brands of ziprasidone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush ziprasidone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using ziprasidone?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of ziprasidone or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not use this medicine if you have heart rhythm disorder, a history of Long QT syndrome, uncontrolled heart failure, or if you have recently had a heart attack.

Ziprasidone is not approved for use in psychotic conditions related to dementia. Ziprasidone may increase the risk of death in older adults with dementia-related conditions.

Some medicines can cause unwanted or dangerous effects when used with ziprasidone, and should not be used at the same time. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Stop taking ziprasidone and call your doctor right away if you have a chest pain, severe dizziness, and a fast or pounding heartbeat. These could be signs of a serious heart rhythm problem.

Stop using this medicine and call your doctor right away if you have a new or worsening skin rash with fever or swollen glands.

Ziprasidone is not approved for use by anyone younger than 18 years old.

While you are taking ziprasidone, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking ziprasidone.

Ziprasidone may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.

Avoid drinking alcohol. Dangerous side effects could occur.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using ziprasidone during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking ziprasidone. Ziprasidone is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from ziprasidone?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have symptoms of a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, unusual bruising, or jaundice (yellowing of your skin or eyes).

Also call your doctor at once if you have:

  • A light-headed feeling, like you might pass out
  • Chest pain, fast or pounding heartbeats
  • Uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement)
  • Low white blood cell counts–sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, pain when swallowing
  • High blood sugar–increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss
  • Severe nervous system reaction–very stiff (rigid) muscles, high fever, sweating, confusion, agitation

Common side effects may include:

  • Dizziness, drowsiness, unusual tiredness
  • Nausea, upset stomach
  • Diarrhea, constipation
  • Feeling restless
  • Tremors
  • Rash
  • Runny nose, new or worsening cough

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with ziprasidone?

Ziprasidone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Anagrelide
  • Methadone
  • Tacrolimus
  • Medicine to prevent nausea or vomiting–dolasetron, droperidol, ondansetron
  • An antibiotic–azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine
  • Cancer medicine–arsenic trioxide, vandetanib
  • An antidepressant–citalopram, escitalopram
  • Anti-malaria medication–chloroquine, halofantrine, mefloquine
  • Heart rhythm medicine–amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol
  • Medicine to treat a psychiatric disorder–chlorpromazine, haloperidol, mesoridazine, pimozide, thioridazine

Does food or alcohol interact with ziprasidone?

Ziprasidone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with ziprasidone?

Ziprasidone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Any heart problems
  • A heart attack or stroke
  • A bone marrow or blood cell disorder
  • Breast cancer
  • Low blood levels of potassium or magnesium
  • Diabetes (ziprasidone may raise your blood sugar)
  • Seizures or epilepsy
  • Suicidal thoughts
  • Alzheimer’s disease
  • Trouble swallowing
  • Liver disease
  • Kidney disease

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using ziprasidone.

What is the dose of ziprasidone for an adult?

Usual Adult Dose for Schizophrenia:

Oral:

  • Initial dose: 20 mg orally twice a day
  • Maintenance dose: Adjust as clinically indicated at intervals of not less than 2 days
  • Maximum dose: 100 mg twice a day

Intramuscular:

  • Recommended dose: 10 to 20 mg IM; may repeat 10 mg IM every 2 hours or 20 mg IM every 4 hours up to maximum daily dose
  • Maximum dose: 40 mg IM per day
  • Duration of therapy: Use beyond 3 consecutive days has not been studied

Usual Adult Dose for Bipolar Disorder:

Acute Treatment of Manic or Mixed Episodes:

  • Initial dose: 40 mg orally twice daily
  • Increase dose to 60 mg or 80 mg twice daily on the second day; subsequently adjust dose based on tolerance and efficacy within the dose range of 40 to 80 mg orally twice a day

Maintenance Treatment (as adjunct to lithium or valproate): Once stabilized, continue on same dose within the range of 40 to 80 mg orally twice daily.

What is the dose of ziprasidone for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is ziprasidone available?

Ziprasidone is available in the following dosage forms and strengths:

  • Capsule
  • Injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of ziprasidone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 20, 2017 | Last Modified: November 20, 2017