Generic Name: Zaleplon Brand Name(s): Zaleplon.


What is Zaleplon used for?

Zaleplon is commonly used to treat sleep problems.

How should I take Zaleplon?

Use zaleplon as ordered by your doctor. Read all information given to you. Follow all instructions closely.

Take this medicine either right before bedtime or after you have already gone to bed and are having trouble falling asleep.

Do not take with or right after a meal.

Do not take zaleplon unless you can get a full night’s sleep (at least 7 to 8 hours) before you need to be active again.

If you still have trouble sleeping after 7 to 10 days, call your doctor.

How do I store Zaleplon?

Zaleplon is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Zaleplon in the bathroom or the freezer. There may be different brands of Zaleplon that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Zaleplon down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Zaleplon?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Zaleplon or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have liver disease.
  • You are breast-feeding. Do not breast-feed while you take zaleplon.
  • The patient is a child. Do not give this medicine to a child.

Tell all of your health care providers that you take zaleplon. This includes your doctors, nurses, pharmacists, and dentists.

Avoid driving and doing other tasks or actions that call for you to be alert after you take this medicine. You may still feel sleepy the day after you take zaleplon. Avoid these tasks or actions until you feel fully awake.

If you are allergic to tartrazine, talk with your doctor. Some products have tartrazine.

This medicine may be habit-forming with long-term use.

When sleep drugs are used nightly for more than a few weeks, they may not work as well to help sleep problems. This is known as tolerance. Only use sleep drugs for a short time. If sleep problems last, call the doctor.

If you have been taking this medicine on a regular basis and you stop it all of a sudden, you may have signs of withdrawal. Do not stop taking zaleplon all of a sudden without calling your doctor. Tell your doctor if you have any bad effects.

Avoid drinking alcohol while taking this medicine.

Talk with your doctor before you use other drugs and natural products that slow your actions.

Some people have done certain tasks or actions while they were not fully awake like driving, making and eating food, and having sex. Most of the time, people do not remember doing these things. Tell your doctor if this happens to you.

A very bad reaction called angioedema has happened with zaleplon. Sometimes, this may be life-threatening. Signs may include swelling of the hands, face, lips, eyes, tongue, or throat; trouble breathing; trouble swallowing; or unusual hoarseness. Talk with the doctor.

If you are 65 or older, use this medicine with care. You could have more side effects.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Zaleplon during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Zaleplon. Zaleplon is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Zaleplon?

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Feeling confused.
  • Hallucinations (seeing or hearing things that are not there).
  • Memory problems or loss.
  • Change in the way you act.
  • Feeling agitated.
  • Change in balance.
  • Feeling very tired or weak.
  • Numbness or tingling.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Zaleplon?

Zaleplon may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Zaleplon?

Zaleplon may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Zaleplon?

Zaleplon may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Zaleplon.

What is the dose of Zaleplon for an adult?

Usual Adult Dose for Insomnia

Initial Dose: 10 mg orally immediately before bedtime or after going to bed and experiencing difficulty falling asleep.

Maximum Dose: 20 mg

Usual Geriatric Dose for Insomnia

Initial Dose: 5 mg orally immediately before bedtime or after going to bed and experiencing difficulty falling asleep.

Maximum Dose: 10 mg

What is the dose of Zaleplon for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Zaleplon available?

Zaleplon is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Zaleplon, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: November 28, 2017 | Last Modified: November 28, 2017

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