Xeltabine

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Generic Name: Xeltabine Brand Name(s): Generics only. No brands available.

Uses

What is Xeltabine® (capecitabine) used for?

Xeltabine® is used to treat breast, colon, or rectal cancer. It works by slowing or stopping the growth of cancer cells.

How should I take Xeltabine® (capecitabine)?

Take this drug by mouth as directed by your doctor, usually 2 times a day; once in the morning and once in the evening.

Swallow the tablets whole with a full glass of water (8 ounces/240 milliliters) within 30 minutes after a meal. Do not crush or split the tablets. Xeltabine® is usually taken every day for 2 weeks, then stopped for 1 week for each treatment cycle.

The dosage is based on your medical condition, body size, and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

How do I store Xeltabine® (capecitabine)?

Xeltabine® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Xeltabine® in the bathroom or the freezer. There may be different brands of Xeltabine® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Xeltabine® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Xeltabine® (capecitabine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Xeltabine® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Capecitabine can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Older adults may be more sensitive to the side effects of this medication, especially nausea, vomiting, diarrhea, and hand-foot syndrome.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Xeltabine® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Xeltabine®. Xeltabine® is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Xeltabine® (capecitabine)?

Some side effects may occur while using this drug, including:

  • Nausea
  • Vomiting
  • Loss of appetite
  • Constipation
  • Tiredness
  • Weakness
  • Headache
  • Dizziness/ lightheadedness
  • Trouble sleeping
  • Changes in taste
  • Diarrhea
  • Unusual decreased urination
  • Unusual dry mouth/thirst
  • Temporary hair loss
  • Skin problem

Stop taking capecitabine and tell your doctor right away if any of these very serious side effects occur:

  • Severe nausea/vomiting (vomiting 2 or more times per day, unable to eat or keep food/fluids in your stomach)
  • Painful redness/swelling/sores in mouth or on your tongue
  • Easy bruising/bleeding
  • Mental/mood changes (such as depression)
  • Swelling of the ankles/feet
  • Vision changes
  • Signs of kidney problems (such as change in the amount of urine)
  • Yellowing eyes/skin
  • Dark urine
  • Trouble breathing

Get medical help right away if you have any very serious side effects, such as:

  • Chest/jaw/left arm pain
  • Unusual sweating
  • Fainting
  • Slow/fast/irregular heartbeat

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Xeltabine® (capecitabine)?

Xeltabine® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Xeltabine® (capecitabine)?

Xeltabine® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Xeltabine® (capecitabine)?

Xeltabine® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions may include:

  • Lack of a certain enzyme (dihydropyrimidine dehydrogenase – DPD)
  • Blood disorders (such as bone marrow suppression)
  • Heart problems (such as heart failure)
  • Kidney disease
  • Liver problems

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Xeltabine® (capecitabine).

What is the dose of Xeltabine® (capecitabine) for an adult?

Colorectal Cancer

For first line treatment of patients with metastatic colorectal carcinoma when treatment with fluoropyrimidine therapy alone:

  • The recommended dose is 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a week rest period given as 3 week cycles.

Adjuvant treatment in patients with dukes’ c colon cancer:

  • The recommended dose is 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a week rest period given as 3 week cycles for a total of 8 cycles (24 weeks).

Breast Cancer

The recommended dose is 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a week rest period given as 3 week cycles.

In combination with docetaxel:

The recommended dose is 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a week rest period combined with docetaxel 75 mg/m2 as an hour IV infusion, every 3 weeks.

What is the dose of Xeltabine® (capecitabine) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Xeltabine® (capecitabine) available?

Xeltabine® is available in the following dosage forms and strengths:

  • Tablet 500mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Xeltabine®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Sources

Review Date: April 20, 2017 | Last Modified: April 20, 2017

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