Generic Name: Versed Brand Name(s): Generics only. No brands available.

Uses

What is Versed® (midazolam) used for?

Versed® is a benzodiazepine sedative.

Versed® is used to sedate a person who is having a minor surgery, dental work, or other medical procedure.

Versed® may also be used for purposes not listed in this medication guide.

How should I take Versed® (midazolam)?

Versed® can slow or stop your breathing, especially if you have recently used a narcotic (opioid) medication. Versed® should be used only in a hospital, dentist office, or other clinic setting where any serious side effects can be quickly treated.

Versed® is usually given as a single dose just before your surgery or procedure.

After you take midazolam, you will be watched closely to make sure the medicine is working and does not cause harmful side effects.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are in surgery.

Versed® can make you very drowsy, dizzy, or light-headed. These effects may last longer in older adults. Use caution to avoid falling or accidental injury after you have received midazolam injection. You may need help getting out of bed for at least the first 8 hours.

How do I store Versed® (midazolam)?

Versed® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Versed® in the bathroom or the freezer. There may be different brands of Versed® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Versed® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Versed® (midazolam)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Versed® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not take this medicine if:

  • You have narrow-angle glaucoma.
  • You are allergic to cherries.
  • You are allergic to midazolam or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

To make sure midazolam is safe for you, tell your doctor if you have:

  • Open-angle glaucoma
  • Asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems
  • Kidney or liver disease
  • Congestive heart failure
  • If you also use a narcotic (opioid) medication

Midazolam can cause birth defects in an unborn baby, and generally should not be used during pregnancy. Tell your doctor if you are pregnant.

Midazolam can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Versed® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Versed®. Versed® is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Versed® (midazolam)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • Cough, wheezing, trouble breathing, weak or shallow breathing
  • Slow heart rate
  • A light-headed feeling, like you might pass out
  • Agitation, hostility, tremors
  • Confusion, hallucinations, unusual thoughts or behavior

The sedative effects of midazolam may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking midazolam.

Common side effects may include:

  • Amnesia or forgetfulness after your procedure
  • Drowsiness, dizziness
  • Nausea, vomiting
  • Runny nose, sneezing
  • Blurred vision

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Versed® (midazolam)?

Versed® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Antifungal medicine
  • An antibiotic
  • An antidepressant
  • Heart or blood pressure medicine
  • Antiviral medicine to treat hepatitis C or HIV/AIDS
  • Seizure medication
  • Tuberculosis medication

Does food or alcohol interact with Versed® (midazolam)?

Versed® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Versed® (midazolam)?

Versed® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Versed® (midazolam).

What is the dose of Versed® (midazolam) for an adult?

Usual Adult Dose for Light Sedation

Patients younger than 60 years:

IM:

  • Usual dose: 0.07 to 0.08 mg/kg IM once, up to 1 hour before surgery

IV:

  • Usual dose: 1 to 2.5 mg slow IV every 2 minutes as necessary for sedation
  • Maintenance dose: After thorough clinical evaluation, additional doses may be given in increments of 25% of the initial dose used to reach sedation.
  • Maximum dose: 2.5 mg/dose

Usual Adult Dose for Light Anesthesia

Patients younger than 55 years:

Premedicated patients:

  • Usual dose: 0.25 mg/kg IV once, administered over 20 to 30 seconds. Healthcare providers should allow 2 minutes for effect.

Unpremedicated patients:

  • Initial dose: 0.3 to 0.35 mg/kg IV once, administered over 20 to 30 seconds. Healthcare providers should allow 2 minutes to for effect. If induction is not complete after 2 minutes, inhalation anesthetics and/or further doses of this drug in increments of 25% of the initial dose may be given.
  • Maximum dose: 0.6 mg/kg

Usual Geriatric Dose for Light Sedation

60 years and older:

IM:

  • Usual dose: 0.02 to 0.05 mg/kg IM once up to 1 hour before surgery

IV:

  • Usual dose: 1 mg slow IV every 2 minutes as needed for sedation
  • Maintenance dose: 25% of the dose used to reach desired sedation level

Usual Geriatric Dose for Light Anesthesia

Over 55 years:

Premedicated patients:

  • Usual dose: 0.2 mg/kg IV once, administered over 20 to 30 seconds

Unpremedicated patients:

  • Usual dose: 0.2 to 0.3 mg/kg IV once, administered over 20 to 30 seconds

What is the dose of Versed® (midazolam) for a child?

Usual Pediatric Dose for Light Sedation

Oral:

6 months to 16 years:

  • Usual dose: 0.25 to 1 mg/kg orally once before the procedure
  • Maximum dose: 20 mg

Parenteral:

IM administration:

  • Usual dose: 0.1 to 0.15 mg/kg IM once, with some patients requiring doses of 0.5 mg/kg
  • Maximum total dose: 10 mg

IV administration:

6 months to 5 years:

  • Initial dose: 0.05 to 0.1 mg/kg IV injection, with evaluation for sedation. If an optimal sedation levels is not reached after 2 to 3 minutes, doses may be readministered every 2 to 3 minutes, up to a maximum dose of 0.6 mg/kg.
  • Maximum total dose: 6 mg

6 years to 12 years:

  • Initial dose: 0.025 to 0.05 mg/kg IV injection, with evaluation for sedation. If an optimal sedation level is not reached, doses may be re-administered every 2 to 3 minutes, up to a maximum dose of 0.4 mg/kg.
  • Maximum total dose: 10 mg

12 years and older:

  • Usual dose: 1 to 2.5 mg slow IV every 2 minutes as necessary for sedation
  • Maintenance dose: After thorough clinical evaluation, additional doses may be given in increments of 25% of the initial dose used to reach sedation.
  • Maximum total dose: 10 mg

Usual Pediatric Dose for ICU Agitation

Parenteral:

Continuous infusion:

Preterm and term neonates:

Less than 32 weeks with tracheal intubation:

  • Initial dose: 0.03 mg/kg/hr (0.5 mcg/kg/min) IV

Over 32 weeks with tracheal intubation:

  • Initial dose: 0.06 mg/kg/hr (1 mcg/kg/min) IV

Non-neonates and children:

Unpremedicated patients with tracheal intubation:

  • Loading dose: 0.05 to 0.2 mg/kg IV once, administered over 2 to 3 minutes
  • Initial dose: 0.06 to 0.12 mg/kg/hr (1 to 2 mcg/kg/min)

Premedicated patients with tracheal intubation:

  • Initial dose: 0.06 to 0.12 mg/kg/hr (1 to 2 mcg/kg/min)

Hemodynamically compromised patients:

  • Loading dose: The usual loading dosed should be increased in small increments.

How is Versed® (midazolam) available?

Versed® is available in the following dosage forms and strengths:

  • Injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Versed®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: August 25, 2017 | Last Modified: August 25, 2017

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