By Medically reviewed by hellodoktor

Generic Name: Verospiron Brand Name(s): Generics only. No brands available.


What is Verospiron® (Spironolactone) used for?

Verospiron® is commonly used to treat:

  • Essential hypertension (high blood pressure with an unknown cause)
  • Hypokalemia (potassium deficiency)
  • Edema (fluid retention) from various conditions, including congestive heart failure, kidney disease, and cirrhosis (liver scarring)
  • Severe heart failure

Verospiron® may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take Verospiron® (Spironolactone)?

  • Do not crush, break, or chew the tablets/capsules.
  • Swallow Verospiron® whole with a glass of water.

Ask your health care provider any questions you may have about how to use medication.

How do I store Verospiron® (Spironolactone)?

Verospiron® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Verospiron® in the bathroom or the freezer. There may be different brands of Verospiron® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Verospiron® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Verospiron® (Spironolactone)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Verospiron® or other medications.
  • You have any other illnesses, disorders, or medical conditions, such as stomach or bowel problems, liver problems or unexplained abnormal liver function tests, or kidney problems.
  • You have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Verospiron® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. Verospiron® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding.

Side effects

What side effects can occur from Verospiron® (Spironolactone)?

Common side effects of spironolactone are

  • Vomiting, diarrhea, and stomach pain or cramps
  • Dry mouth and thirst
  • Dizziness, unsteadiness, and headache
  • Gynecomastia (enlarged breast tissue) in men, and breast pain in women
  • Irregular menstrual periods and post-menopausal vaginal bleeding
  • Erectile dysfunction
  • Deepening of the voice and increased hair growth
  • Drowsiness, tiredness, and restlessness

Severe side effects of spironolactone are

  • Muscle pain or weakness
  • Numbness or tingling
  • Paralysis in the arms or legs
  • Arrhythmia
  • Confusion, extreme tiredness, and fainting
  • Unusual bleeding or bruising
  • Life-threatening skin reactions
  • Flu-like symptoms, pain in the upper right abdomen
  • Loss of appetite
  • Vomiting blood
  • Bloody stools
  • Difficulty breathing or swallowing
  • Decreased urination

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Verospiron® (Spironolactone)?

Verospiron® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Verospiron® may cause interactions with these medications:

  • Lithium (Eskalith, Lithobid)
  • ACE inhibitors, such as benazepril (Lotensin)
  • Angiotensin II receptor blockers, such as azilsartan (Edarbi)
  • Digoxin (Lanoxin)
  • Cholestyramine (Questran, Cholybar)
  • Steroids such as prednisone
  • Ibuprofen (Advil) and other nonsteroidal anti-inflammatory drugs
  • Inspra (Eplerenone) and other aldosterone receptor antagonists
  • Heparin (Hemochron, Hep-Lock) and low-molecular-weight heparin (Lovenox)
  • Skeletal muscle relaxers, including cyclobenzaprine (Amrix, Flexeril)
  • Other diuretics, such as amiloride (Midamor)
  • Norepinephrine
  • Potassium supplements

Does food or alcohol interact with Verospiron® (Spironolactone)?

Verospiron® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Verospiron® (Spironolactone)?

Verospiron® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Anuria
  • Severe renal impairment, acute renal insufficiency
  • Addison’s disease or other conditions associated with hyperkalemia
  • Co-administration with eplerenone


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Verospiron® (Spironolactone) for an adult?

Primary hyperaldosteronism:

100 to 400 mg daily.


25 to 200 milligrams every day, for at least 5 days.

Essential hypertension:

50 to 100 mg every day, for at least two weeks.


25 to 100 mg once daily.

Severe heart failure:

25 mg once daily, which may be increased to 50 mg once daily or decreased to 25 mg once every other day, depending on your tolerance of the drug.

What is the dose of Verospiron® (Spironolactone) for a child?


Starting dose: 1-3.3 mg / kg body weight or 30-90 mg / m2/sut 1-4 admission. Through 5 days, dose correction is performed, if necessary, to increase its 3 times compared to original.

How is Verospiron® (Spironolactone) available?

Verospiron® is available in the following dosage forms and strengths:

  • Verospiron® Tablet 25mg
  • Verospiron® Capsule 50mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

It is also important to carry a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking with you in case of emergencies.

What should I do if I miss a dose?

If you miss a dose of Verospiron®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: December 15, 2016 | Last Modified: September 12, 2019