Generic Name: Vecuronium Brand Name(s): Generics only. No brands available.

Uses

What is vecuronium used for?

Vecuronium is a neuromuscular blocking agent. It works by blocking nerve transmissions in muscle nerves, which results in muscle relaxation and paralysis.

Vecuronium is commonly used for relaxing muscles during surgery and mechanical breathing.

How should I take vecuronium?

Vecuronium is usually administered as an injection by your doctor.

How do I store vecuronium?

Vecuronium is usually handled and stored by a health care provider. If you are using vecuronium at home, store vecuronium as directed by your pharmacist or health care provider.

Precautions & warnings

What should I know before using vecuronium?

Before using this drug, tell your doctor if:

  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.
  • You are allergic to any ingredient in vecuronium.
  • You have diarrhea due to poisoning or pseudomembranous colitis.

Also, you should know that:

  • Vecuronium may cause a change in circulation time for patients with heart problems or increased age.
  • Patients with severe obesity or neuromuscular disease may have airway and/or breathing problems requiring special care before, during, and after the use of neuromuscular blocking agents such as vecuronium.
  • Neuroleptic malignant syndrome (NMS) is a potentially deadly syndrome associated with vecuronium. Symptoms may include increased body heat; rigid muscles; altered mental abilities, including lack of response to your surroundings; fast or irregular heartbeat; and sweating. Contact your doctor at once if any of these symptoms occur.
  • Use vecuronium with caution in the elderly because they may be more sensitive to its effects.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from vecuronium?

Some side effects may include:

  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Dizziness
  • Fever
  • Prolonged muscle weakness
  • Unusually fast or slow heart rate

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with vecuronium?

Vecuronium may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Aminoglycosides (e.g., gentamicin)
  • Clindamycin
  • Cyclosporine
  • Inhalation anesthetics (e.g., enflurane)
  • Lincomycin
  • Magnesium salts
  • Polypeptide antibiotics (e.g., bacitracin)
  • Quinidine
  • Quinine
  • Trimethaphan
  • Verapamil
  • Carbamazepine
  • Hydantoins
  • Other nondepolarizing neuromuscular blockers (e.g., pancuronium)
  • Tetracyclines (e.g., doxycycline)
  • Theophyllines
  • Thiopurines

Does food or alcohol interact with vecuronium?

Vecuronium may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with vecuronium?

Vecuronium may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • A history of asthma
  • An enlarged prostate
  • Trouble urinating
  • Circulation problems
  • Electrolyte problems
  • A blockage of your bladder
  • Irregular heartbeat or other heart problems
  • Liver or kidney problems
  • Adrenal gland problems
  • Underactive thyroid
  • Lung problems (chronic obstructive pulmonary disease [COPD], cor pulmonale)
  • Myasthenia gravis or Eaton-Lambert syndrome
  • Mood or mental problems
  • Suicidal thoughts or behaviors
  • Serious head injury
  • Increased pressure in the brain
  • Unusual growths in the brain
  • Seizures
  • Severe inflammatory bowel disease
  • A history of substance abuse
  • Stomach or intestinal surgery

 

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using vecuronium.

What is the dose of vecuronium for an adult?

Initially, the recommended dose is 0.08 to 0.1 mg/kg. Maintenance dose during prolonged surgical procedures is 0.01 to 0.015 mg/kg 25 to 40 minutes later, then as frequently as every 12 to 15 minutes.

Continuous infusion: Initiate with an intubating dose is 80 to 100 mcg/kg followed 20 to 40 minutes later with 0.8 to 1.2 mcg/kg/minute.

What is the dose of vecuronium for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is vecuronium available?

Vecuronium is available in the following dosage forms and strengths:

  • Syringe 4mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of vecuronium, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: February 6, 2017 | Last Modified: February 6, 2017

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