Generic Name: Valrubicin Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C

Uses

What is Valrubicin used for?

Valrubicin is used to treat bladder cancer. The usual treatment for bladder cancer is surgery. However, if you and your doctor decide that the risk of surgery is greater than its benefit or that surgery may be delayed, this medication may be used as part of your treatment.

This medication belongs to a class of drugs known as anthracyclines and works by slowing or stopping the growth of cancer cells.

This medication may not cure your cancer. Delaying surgery could lead to a more serious illness (metastatic cancer). Discuss the risks and benefits of this medication with your doctor.

How should I take Valrubicin?

This medication is given by placement into the bladder as directed by your doctor. Do not give by injection into a vein or muscle or under the skin. After this medication is placed through a tube (catheter), it is usually left in the bladder for 2 hours, then released by urinating. This drug is usually used once weekly for 6 weeks or as directed by your doctor.

Drink plenty of fluids after each treatment with this medication unless otherwise directed by your doctor. Doing so helps clear it from your body and decrease side effects.

How do I store Valrubicin?

Valrubicin is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Valrubicin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Valrubicin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Valrubicin?

Before using valrubicin, tell your doctor or pharmacist if you are allergic to it; or to other anthracyclines (e.g., doxorubicin); or if you have any other allergies. This product may contain inactive ingredients (such as polyoxyethylated castor oil), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: small bladder size or other bladder problems (e.g., perforation, incontinence), current urinary infection/symptoms of bladder irritation (including pain, spasm, frequent urge to urinate).

This medication is not recommended for use during pregnancy. It may harm an unborn baby. If you become pregnant or think you may be pregnant, tell your doctor right away. To avoid pregnancy, both males and females using this drug should use reliable form(s) of birth control (e.g., birth control pills, condoms) during treatment. Consult your doctor for details and to discuss effective forms of birth control.

It is not known whether this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Valrubicin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Valrubicin. Valrubicin is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Valrubicin?

Bladder irritation, with symptoms such as pain, spasm, and frequent urge to urinate, usually occurs. This medication usually will cause your urine to turn a reddish color. This is a normal, harmless effect of the drug and should not be mistaken for blood in your urine. If any of these effects persist or worsen after 24 hours, contact your doctor right away.

Infrequent side effects include nausea, abdominal/stomach pain, diarrhea, headache, weakness, dizziness, or back pain. If any of these effects persist or worsen, tell your doctor.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: bloody urine, signs of infection (e.g., fever, chills), unusual tiredness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), trouble breathing, severe dizziness.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Valrubicin?

Valrubicin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Valrubicin?

Valrubicin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Valrubicin?

Valrubicin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Valrubicin.

What is the dose of Valrubicin for an adult?

Usual Adult Dose for Urinary Tumor

Usual Adult Dose: 800 mg administered intravesically once a week for six weeks.

Comments:

-Delay administration at least two weeks after transurethral resection and/or fulguration.

-Patients should retain the drug for two hours before voiding, if they are able. At the end of two hours, all patients should void.

Use: For intravesical therapy of BCG-refractory carcinoma in situ (CIS) of the urinary bladder in patients for whom immediate cystectomy would be associated with unacceptable morbidity or mortality.

Other comments

Monitoring:

-Monitor closely for disease recurrence or progression.

-Recommended evaluations include cystoscopy, biopsy, and urine cytology every 3 months.

What is the dose of Valrubicin for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Valrubicin available?

Valrubicin is available in the following dosage forms and strengths:

  • Irrigation solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Valrubicin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

 

Sources

Review Date: July 27, 2018 | Last Modified: July 27, 2018

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