By Medically reviewed by hellodoktor

Generic Name: Valdecoxib Brand Name(s): Valdecoxib.


What is Valdecoxib used for?

Valdecoxib is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Valdecoxib works by reducing substances in the body that cause inflammation, pain, and fever.

Valdecoxib is used to reduce pain, inflammation, and stiffness caused by osteoarthritis and adult rheumatoid arthritis. Valdecoxib is also used to treat painful menstruation.

Valdecoxib may also be used for purposes other than those listed in this medication guide.

How should I take Valdecoxib?

Take valdecoxib exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Valdecoxib can be taken with or without food or milk. Follow your doctor’s instructions.

How do I store Valdecoxib?

Valdecoxib is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Valdecoxib in the bathroom or the freezer. There may be different brands of Valdecoxib that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Valdecoxib down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Valdecoxib?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Valdecoxib or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You smoke.
  • You drink alcohol.
  • You have an ulcer or bleeding in the stomach.
  • You have liver disease.
  • You have kidney disease.
  • You have asthma.
  • You have congestive heart failure.
  • You have fluid retention.
  • You have heart disease.
  • You have high blood pressure.
  • You have a coagulation (bleeding) disorder or are taking an anticoagulant (blood thinner) such as warfarin (Coumadin).
  • You are taking a steroid medicine such as prednisone (Deltasone and others), methylprednisolone (Medrol and others), prednisolone (Prelone, Pediapred, and others), and others.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Valdecoxib during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Valdecoxib. Valdecoxib is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Valdecoxib?

Serious skin reactions have occurred in patients taking valdecoxib. These reactions tend to occur within the first two weeks of treatment, but may occur at any time during treatment. Stop taking valdecoxib and contact your doctor immediately if you develop a skin rash; hives; itching; difficulty breathing; swelling of the lips, tongue or face; or other symptoms of an allergic reaction.

Notify your doctor immediately if you develop abdominal pain, tenderness, or discomfort; nausea; bloody vomit; bloody, black, or tarry stools; unexplained weight gain; swelling or water retention; fatigue or lethargy; a skin rash; itching; yellowing of the skin or eyes; “flu-like” symptoms; or unusual bruising or bleeding. These symptoms could be early signs of dangerous side effects.

Other, less serious side effects may be more likely to occur. Continue to take valdecoxib and talk to your doctor if you experience:

  • Diarrhea
  • Nausea or upset stomach
  • Headache

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Valdecoxib?

Valdecoxib may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan’s, Bayer Select Backache Formula, others)
  • An over-the-counter cough, cold, allergy, or pain medicine that contains dextromethorphan, aspirin, ibuprofen, naproxen, or ketoprofen
  • A diuretic (water pill) such as furosemide (Lasix), hydrochlorothiazide (HydroDiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Hygroton, Thalitone), and others
  • An angiotensin-converting-enzyme inhibitor (ACE inhibitor) such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), and others
  • A steroid medicine such as prednisone (Deltasone and others), methylprednisolone (Medrol and others), prednisolone (Prelone, Pediapred, and others), and others
  • An anticoagulant (blood thinner) such as warfarin (Coumadin)
  • Diazepam (Valium)
  • Phenytoin (Dilantin)
  • Glyburide (DiaBeta, others)
  • An oral contraceptive (Micronor, Triphasil, Levlen, others)
  • Omeprazole (Prilosec, Zegerid)
  • Lithium (Eskalith, Lithobid, others)
  • Fluconazole (Diflucan) or ketoconazole (Nizoral)

Does food or alcohol interact with Valdecoxib?

Valdecoxib may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Valdecoxib?

Valdecoxib may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Valdecoxib.

What is the dose of Valdecoxib for an adult?

Usual Adult Dose for Osteoarthritis:

Initial dose: 10 mg once daily

Usual Adult Dose for Rheumatoid Arthritis:

Initial dose: 10 mg once daily

Usual Adult Dose for Dysmenorrhea:

Initial dose: 20 mg twice daily

What is the dose of Valdecoxib for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Valdecoxib available?

Valdecoxib is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Valdecoxib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: November 23, 2017 | Last Modified: September 12, 2019

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