Generic Name: Uromitexan Brand Name(s): Generics only. No brands available.


What is Uromitexan® (mesna) used for?

Uromitexan® is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer). Uromitexan® is in a class of medications called cytoprotectants. It works by protecting against some of the harmful effects of certain chemotherapy medications.

How should I take Uromitexan® (mesna)?

Uromitexan® is usually given as a drip (infusion) at the same time as your chemotherapy. The infusion will be given through a fine tube (cannula) inserted into a vein.

How do I store Uromitexan® (mesna)?

Uromitexan® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Uromitexan® in the bathroom or the freezer. There may be different brands of Uromitexan® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Uromitexan® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Uromitexan® (mesna)?

Before receiving Uromitexan® injection, tell your doctor:

  • If you are allergic to Uromitexan®, any other medications, or any of the ingredients in Uromitexan® injection.
  • What prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
  • If you have or have ever had an autoimmune disorder (a condition that occurs when your immune system mistakenly attacks healthy body tissue) such as rheumatoid arthritis, systemic lupus erythematosus, or nephritis (a type of kidney problem).
  • If you are pregnant, plan to become pregnant, or are breastfeeding.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Uromitexan® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Uromitexan®.

Side effects

What side effects can occur from Uromitexan® (mesna)?

Uromitexan® may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • Nausea
  • Vomiting
  • Constipation
  • Loss of appetite or weight
  • Diarrhea
  • Abdominal pain
  • Headache
  • Tiredness
  • Dizziness
  • Hair loss
  • Pain or redness at the place where the injection was given
  • Loss of strength and energy
  • Fever
  • Sore throat
  • Cough
  • Flushing

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • Pink or red colored urine or blood in urine
  • Swelling of the face, arms, or legs
  • Hives
  • Rash
  • Itching
  • Difficulty breathing or swallowing
  • Chest pain
  • Fast, irregular, or pounding heartbeat
  • Unusual bleeding or bruising

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Uromitexan® (mesna)?

Uromitexan® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Uromitexan® (mesna)?

Uromitexan® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Uromitexan® (mesna)?

Uromitexan® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Uromitexan® (mesna).

What is the dose of Uromitexan® (mesna) for an adult?

Uromitexan® comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given at the same time as you receive your chemotherapy treatment and then 4 and 8 hours after your chemotherapy treatment.

Drink at least 1 quart (4 cups; about 1 liter) of fluid daily while you are receiving Uromitexan® injection.

What is the dose of Uromitexan® (mesna) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Uromitexan® (mesna) available?

Uromitexan® is available in the following dosage forms and strengths:

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Uromitexan®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.



Review Date: February 6, 2017 | Last Modified: February 6, 2017

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