Generic Name: Urokinase Brand Name(s): Generics only. No brands available.

Uses

What is Urokinase used for?

Urokinase is a thrombolytic drug, sometimes called a “clot-busting” drug. It helps your body produce a substance that dissolves unwanted blood clots.

Urokinase is used to treat blood clots in the lungs.

Urokinase may also be used for purposes not listed in this medication guide.

How should I take Urokinase?

Urokinase is injected into a vein through an IV. A healthcare provider will give you this injection.

Urokinase is given slowly, usually over a period of 12 hours, using a continuous infusion pump.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving urokinase.

After treatment with urokinase, your doctor may prescribe a blood thinner or other medication to help prevent future blood clots. Carefully follow all dosing instructions. These medications can make it easier for you to bleed, even from a minor injury.

How do I store Urokinase?

Urokinase is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Urokinase in the bathroom or the freezer. There may be different brands of Urokinase that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Urokinase down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Urokinase?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Urokinase or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You are pregnant or have had a baby within the past 10 days.
  • You have had surgery or an organ transplant within the past 10 days.

You should not be treated with urokinase if you are allergic to it, or if you have:

  • Active bleeding inside your body
  • A brain tumor or blood vessel disorder
  • A brain aneurysm (dilated blood vessel)
  • A bleeding or blood clotting disorder (such as hemophilia)
  • Severe or uncontrolled high blood pressure
  • A recent medical emergency requiring CPR (cardiopulmonary resuscitation)
  • A stroke, brain surgery, or spinal surgery within in the past 2 months.

In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.

Urokinase is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Urokinase during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Urokinase. Urokinase is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Urokinase?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Urokinase increases your risk of bleeding, which can be severe or life-threatening. Call your doctor or seek emergency medical attention if you have bleeding that will not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.

Call your doctor at once if you have signs of bleeding inside your body, such as:

  • Easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection)
  • Bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
  • Red or pink urine
  • Sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance

Some side effects may occur during or within 1 hour after the injection. Tell your caregiver right away if you feel chilled or feverish, nauseated, light-headed, or have chest tightness, back pain, trouble breathing, or fast heartbeats.

Also call your doctor at once if you have:

  • Chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling
  • Swelling, rapid weight gain, little or no urinating
  • Severe stomach pain, nausea, and vomiting
  • Darkening or purple discoloration of your fingers or toes
  • Very slow heartbeats, shortness of breath, feeling light-headed
  • Sudden severe back pain, muscle weakness, numbness or loss of feeling in your arms or legs
  • Dangerously high blood pressure–severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats
  • Pancreatitis–severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Urokinase?

Urokinase may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • A blood thinner (heparin, warfarin, Coumadin, Jantoven)
  • NSAIDs (nonsteroidal anti-inflammatory drugs) –aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others
  • Medication used to prevent blood clots–abciximab, eptifibatide, tirofiban, vorapaxar

Does food or alcohol interact with Urokinase?

Urokinase may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Urokinase?

Urokinase may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • A history of stroke
  • Severe liver or kidney disease
  • Eye problems caused by diabetes
  • An infection of the lining of your heart (also called bacterial endocarditis)
  • A blood clot of your heart
  • A recent history of stomach or intestinal bleeding

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Urokinase.

What is the dose of Urokinase for an adult?

Usual Adult Dose for Pulmonary Embolism:

Initial dose: 4400 international units/kg IV at a rate of 90 mL/hr over 10 minutes.

Maintenance dose: 4400 international units/kg/hr IV at a rate of 15 mL for 12 hours.

What is the dose of Urokinase for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Urokinase available?

Urokinase is available in the following dosage forms and strengths:

  • Injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Urokinase, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 23, 2017 | Last Modified: November 23, 2017

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