Generic Name: Urografin Brand Name(s): Generics only. No brands available.

Uses

What is Urografin® (sodium diatrizoate, meglumine diatrizoate) used for?

Urografin® is commonly used for diagnostic. It helps to make the area of patient’s body clearer when they do an X-rays.

How should I take Urografin® (sodium diatrizoate, meglumine diatrizoate)?

Urografin® will be injected into a vein. Sometimes, this drug will be injected into your muscles or anus (back passage). The staff in the X-ray department will observe you for 30 minutes after the injection just in case you have any side effects.

How do I store Urografin® (sodium diatrizoate, meglumine diatrizoate)?

Urografin® will be stored by the manufacturer.

Precautions & warnings

What should I know before using Urografin® (sodium diatrizoate, meglumine diatrizoate)?

Do not use Urografin® if:

  • You are allergic (hypersensitive) to any of the other ingredients of Urografin®.
  • You have a condition caused by too much thyroid hormone (uncontrolled thyrotoxicosis).
  • You have severe heart insufficiency (causing edema or shortness of breath).
  • You are pregnant.
  • You have had inflammation of the pelvic cavity (symptoms include stomach pain and tenderness, fever and irregular menstrual periods), you must not have your uterus (womb) investigated with Urografin®.

If the procedure is to look at your abdomen, kidneys or bladder you may be asked to avoid foods that cause flatulence (wind) for two days beforehand. These foods include:

  • Peas
  • Beans
  • Lentils
  • Salads
  • Fruit
  • Brown or granary bread
  • All kinds of uncooked vegetables

You will be told not to eat after 6pm on the day before the examination, but you can still drink.

Babies and young children, however, must not fast. If you have a disorder of your body water and body salts balance, this will be corrected before the examination.

Do not reduce the amount you normally drink before the investigation, especially if you have any of the following:

  • multiple myeloma (disease of the bone marrow)
  • diabetes mellitus
  • polyuria (production of large amounts of urine which is pale in colour)
  • oliguria (production of small amounts of urine)
  • gout

Also, fluid intake must not be reduced in babies, young children, or in someone who is in a very poor general state of health where their body tissues are wasting away.

If you are going to have an iodine test for thyroid disease, tell your doctor or the laboratory staff if you have been given Urografin® recently.

Is it safe during pregnancy or breastfeeding?

Tell the X-ray department staff if you are pregnant, think you may be pregnant, or are breastfeeding.

Side effects

What side effects can occur from Urografin® (sodium diatrizoate, meglumine diatrizoate)?

Like all medicines, Urografin® can cause side effects, although not everybody gets them. Side effects are usually mild and do not last long. However, as with similar contrast media, severe and life-threatening reactions, as well as deaths, have been reported. If you notice:

  • Itching of the skin
  • Rash
  • Wheals on the skin (urticaria)
  • Difficulty breathing
  • Gagging
  • Feeling of suffocation
  • Swelling of the face, neck or body
  • Itchy or watery eyes
  • Tickling in the throat or nose
  • Hoarseness
  • Coughing
  • Sneezing
  • Headache
  • Dizziness
  • Feeling faint
  • Feeling particularly hot or cold
  • Sweating
  • Paleness or reddening of the skin
  • Chest pain
  • Cramp
  • Tremor
  • Feeling sick

Tell the radiologist or X-ray staff immediately as these may be the first signs of allergic reaction or shock. Your investigation will need to be stopped, and you may need further treatment.

Besides, the other possible side effects of Urografin® are:

  • Feeling sick
  • A sensation of pain
  • A general feeling of warmth
  • Redness in the injected area

In rarely case, your kidneys temporarily stop working.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Urografin® (sodium diatrizoate, meglumine diatrizoate)?

Urografin® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, such as:

  • Beta-blockers
  • Interleukin
  • Biguanides

Does food or alcohol interact with Urografin® (sodium diatrizoate, meglumine diatrizoate)?

Urografin® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Urografin® (sodium diatrizoate, meglumine diatrizoate)?

Urografin® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions may include:

  • Reduced liver
  • Kidney function
  • A history of seizures
  • A disease of blood vessels in the brain (cerebral arteriosclerosis)
  • Diabetes mellitus and/or associated with diabetic complications
  • Damaged lungs (pulmonary emphysema)
  • Poor general health
  • An overactive thyroid gland (hyperthyroidism)
  • A swollen neck due to an enlarged thyroid gland (benign nodular goitre)
  • A disease of the bone marrow (multiple myeloma)
  • A history of allergy
  • Poor heart function
  • Blood circulation
  • Polyuria
  • Oliguria
  • Gout

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Urografin® (sodium diatrizoate, meglumine diatrizoate).

What is the dose of Urografin® (sodium diatrizoate, meglumine diatrizoate) for an adult?

The X-ray department staff will decide how much Urografin® is needed for your particular investigation. They will explain how everything works and what position you should lie in on the X-ray table.

The dose of Urografin® varies depending on the investigation and your weight. The dose range is normally between 1 and 500ml.

What is the dose of Urografin® (sodium diatrizoate, meglumine diatrizoate) for a child?

The X-ray department staff will decide how much Urografin® is needed for your particular investigation. They will explain how everything works and what position you should lie in on the X-ray table.

The dose of Urografin® varies depending on the investigation and your weight. The dose range is normally between 1 and 500ml.

How is Urografin® (sodium diatrizoate, meglumine diatrizoate) available?

Urografin® is available in the following dosage forms and strengths:

  • Urografin® 150 is available in packs of ten 10ml ampoules or packs of ten 20ml ampoules.
  • Urografin® 150 for infusion is available in 250ml or 500ml bottles.
  • Urografin® 370 is available in packs of ten 50 ml bottles or one 100ml bottle.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Urografin®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: February 18, 2017 | Last Modified: February 18, 2017

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