Generic Name: Urofollitropin Brand Name(s): Urofollitropin.

Uses

What is Urofollitropin used for?

Urofollitropin is commonly used to treat certain fertility problems in women. It provides the hormone (FSH) that helps cause the ovaries to produce eggs. This medication is usually used in combination with another hormone (hCG) for the growth and release of a mature egg (ovulation).

This medication is not recommended for women whose ovaries no longer make eggs properly (primary ovarian failure).

How should I take Urofollitropin?

Wash your hands with soap and water before using this medication. Before injecting each dose, clean the injection site with rubbing alcohol. It is important to change the location of the injection site daily to avoid discomfort or problem areas under the skin. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.

Inject this medication under the skin or into a muscle, usually once a day or as directed by your doctor.

The dosage and length of treatment are based on your medical condition, response to treatment, laboratory tests, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor will do blood/medical tests (e.g., estradiol blood levels, ultrasound) to find the right dose for you and to decide when to inject the next medication (hCG).

How do I store Urofollitropin?

Store the unmixed medication in the refrigerator or at room temperature between 37-77 degrees F (3-25 degrees C). Protect from light and moisture. Do not freeze. Do not store in the bathroom. Use immediately after mixing. Discard any unused liquid. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

You should not flush Urofollitropin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Urofollitropin?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other fertility problems (e.g., primary ovarian failure), abnormal bleeding from the vagina/uterus, thyroid problems, adrenal gland problems, cancer of the reproductive organs (e.g., breast, uterus, ovary), tumor in the brain (e.g., pituitary tumor), ovarian cysts or enlarged ovaries (not due to polycystic ovary syndrome), twisting of the ovary (ovarian torsion), personal/family history of blood clots, blood clotting disorders (such as thrombophilia), obesity, polycystic ovarian syndrome, stroke, certain heart diseases (e.g., angina, heart attack), lung problems (e.g., asthma).

Multiple births may occur as a result of this treatment. Discuss the risks and benefits of having such a pregnancy with your doctor.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Urofollitropin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this Urofollitropin. This Urofollitropin is pregnancy risk category X according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Urofollitropin?

Headache, nausea, vomiting, mild stomach/abdominal pain, bloating, redness/pain at the injection site, or breast tenderness/pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: unusual bleeding from the vagina/uterus, pain/redness/swelling of the calf muscles, cold/numb/pale skin of the arms/legs/hands/feet, swelling of ankles/hands/feet.

Seek immediate medical attention if any of these rare but very serious side effects occur: weakness on one side of the body, slurred speech, vision changes, sudden severe headache, chest pain, shortness of breath.

This medication may cause a condition known as ovarian hyperstimulation syndrome (OHSS). This condition may occur during treatment and after treatment has been stopped. Rarely, serious OHSS causes fluid to suddenly build up in the stomach, chest, and heart area. Seek immediate medical attention if you develop the following side effects: severe pain or swelling in the lower abdominal (pelvic) area, severe nausea/vomiting, sudden/rapid weight gain, difficult/painful breathing, decreased urination.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Urofollitropin?

Some products that may interact with this drug include: clomiphene, gonadorelin.

Urofollitropin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Urofollitropin?

Urofollitropin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Urofollitropin?

Urofollitropin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Urofollitropin.

What is the dose of Urofollitropin for an adult?

Usual Adult Dose for Follicle Stimulation

Ovulation induction:

  • Initial dose: 150 international units per day for 5 days, subcutaneously (SC) or intramuscularly (IM)
  • Maximum dose: 450 international units per day
  • Duration of therapy: 12 days

Comments:

  • When pre-ovulatory conditions are reached, administer human chorionic gonadotropin (hCG) to induce final oocyte maturation and ovulation.
  • Withhold hCG when monitoring suggests an increased risk of ovarian hyperstimulation syndrome (OHSS) on the last day of therapy.
  • Encourage daily intercourse, beginning on the day prior to hCG and until ovulation becomes apparent.
  • Discourage intercourse when the risk for OHSS is increased.

Assisted reproduction:

Initial dose: 225 international units per day for 5 days, subcutaneously

If given with menotropin, the total combined dose should not exceed 225 international units (150 international units urofollitropin and 75 international units menotropin, or 75 international units urofollitropin and 150 international units menotropin).

Maximum dose: 450 international units per day

If given with menotropin, the total combined dose of urofollitropin and menotropin should not exceed 450 international units per day.

Duration of therapy: 12 days

Comments:

  • Beginning on cycle day 2 or 3, administer daily until sufficient follicular development is attained, as determined by ultrasound and measurement of serum estradiol levels.
  • Continue treatment until adequate follicular development is evident, and then administer hCG.
  • Withhold hCG where monitoring suggests an increased risk of OHSS on the last day of therapy.

Uses:

  • Induction of ovulation in women who have previously received pituitary suppression – intramuscular and subcutaneous administration.
  • Development of multiple follicles as part of an Assisted Reproductive Technology (ART) cycle in ovulatory women who have previously received pituitary suppression.

Dose Adjustments

Ovulation Induction

  • The dosing scheme is stepwise and is individualized for each woman.
  • For women who have received GnRH agonist or pituitary suppression, a starting dose is administered subcutaneously or intramuscularly for 5 days in the first cycle of treatment.
  • In subsequent cycles the starting dose and dosage adjustments should be determined based on ovarian response.
  • Dose adjustments based on clinical monitoring (including serum estradiol levels and vaginal ultrasound results) should be used to prevent multiple follicular growth and cycle cancellation.
  • Do not adjust dose more frequently than once every 2 days and do not exceed 150 international units per adjustment.
  • Use the lowest dose that will achieve desired results.
  • In general, do not exceed 12 days of treatment.

Assisted Reproductive Technology (ART)

  • The recommended dosing scheme for patients undergoing IVF follows a stepwise approach and is individualized for each woman.
  • Adjust the dose after 5 days based on ovarian response, as determined by ultrasound evaluation of follicular growth and serum estradiol levels.
  • Do not adjust dose more frequently than once every 2 days and do not exceed 150 international units per adjustment.
  • In most cases, therapy should not exceed 12 days.

What is the dose of Urofollitropin for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Urofollitropin available?

Urofollitropin is available in the following dosage forms and strengths:

  • Intramuscular powder for injection
  • Injectable powder for injection
  • Subcutaneous powder for injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Urofollitropin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: December 21, 2017 | Last Modified: December 21, 2017

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