Trospium chloride


Generic Name: Trospium chloride Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C


What is Trospium chloride used for?

Trospium chloride is used to treat an overactive bladder. By relaxing the muscles in the bladder, trospium improves your ability to control your urination. It helps to reduce leaking of urine, feelings of needing to urinate right away, and frequent trips to the bathroom. Trospium belongs to a class of drugs known as antispasmodics. It is also known as an antimuscarinic.

How should I take Trospium chloride?

Take this medication by mouth, usually twice daily, 1 hour before a meal or on an empty stomach.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day. Dosage is based on your age, medical condition, and response to therapy.

Tell your doctor if your condition does not improve or if it worsens.

How do I store Trospium chloride?

Trospium chloride is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Trospium chloride in the bathroom or the freezer. There may be different brands of Trospium chloride that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Trospium chloride down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Trospium chloride?

Before taking trospium, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, kidney disease, liver disease, stomach/intestinal problems (such as blockage, constipation, ulcerative colitis), myasthenia gravis, inability to urinate (urinary retention).

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Older adults may be more sensitive to the side effects of this drug, especially constipation, dry mouth, drowsiness, confusion, or trouble urinating. Drowsiness and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Trospium chloride during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Trospium chloride. Trospium chloride is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Trospium chloride?

Dry mouth, constipation, stomach upset, headache, dry eyes, dizziness, blurred vision, or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water or use a saliva substitute.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: eye pain, difficulty urinating, fast heartbeat, mental/mood changes (such as hallucinations, confusion).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Trospium chloride?

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other drugs that are also removed by the kidneys (such as metformin, tenofovir, vancomycin), certain anti-Parkinson’s drugs (such as benztropine, trihexyphenidyl), other antimuscarinic drugs (such as dicyclomine, oxybutynin, scopolamine, tolterodine), potassium tablets/capsules, pramlintide.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness, including alcohol, marijuana, certain antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Trospium chloride may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Trospium chloride?

Trospium chloride may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Trospium chloride?

Trospium chloride may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Trospium chloride.

What is the dose of Trospium chloride for an adult?

Usual Adult Dose for Urinary Incontinence

Immediate-release tablets:

20 mg orally twice daily

Extended-release capsules:

60 mg orally once daily in the morning

Usual Adult Dose for Urinary Frequency

Immediate-release tablets:

20 mg orally twice daily

Extended-release capsules:

60 mg orally once daily in the morning

Usual Geriatric Dose for Urinary Incontinence

Immediate-release tablets:

Greater than or equal to 75 years: 20 mg orally once daily.

Usual Geriatric Dose for Urinary Frequency

Immediate-release tablets:

Greater than or equal to 75 years: 20 mg orally once daily.

Renal Dose Adjustments

Immediate-release tablets:

CrCl 30 mL/min: 20 mg orally once daily at bedtime

Extended-release capsules:

CrCl 30 mL/min: Not recommended

CrCl 30 to 80 mL/min: Data not available

Liver Dose Adjustments

Caution should be exercised when using trospium chloride in patients with moderate and severe hepatic dysfunction.


Trospium chloride is contraindicated in patients with gastric retention, uncontrolled narrow-angle glaucoma, or urinary retention, and in patients who are at risk for these conditions.

Caution should be exercised when using trospium chloride in patients with clinically significant bladder outflow obstruction because of the risk of urinary retention.

Patients treated for narrow-angle glaucoma in whom treatment with trospium chloride is considered to provide benefit should be closely monitored.

Trospium chloride, similarly to other anticholinergic drugs, may decrease gastrointestinal motility and caution should be used when treating patients with conditions such as intestinal atony, ulcerative colitis, and myasthenia gravis.

Trospium chloride should be used with caution in patients with moderate or severe hepatic dysfunction.

What is the dose of Trospium chloride for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Trospium chloride available?

Trospium chloride is available in the following dosage forms and strengths:

  • Oral tablet,
  • Oral capsule, extended release.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Trospium chloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: November 7, 2018 | Last Modified: November 7, 2018

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