Generic Name: Tritanrix Hb Brand Name(s): Generics only. No brands available.


What is Tritanrix Hb used for?

Tritanrix Hb is commonly used for children to prevent diphtheria, tetanus (lockjaw), pertussis (whooping cough), and hepatitis B. This vaccine works by causing the body to produce its own protection (antibodies) against these diseases.

  • Diphtheria: Diphtheria mainly affects the airways and sometimes the skin. Generally, the airways become inflamed (swollen) causing severe breathing difficulties and sometimes suffocation. The bacteria also release a toxin (poison), which can cause nerve damage, heart problems, and even death.
  • Tetanus (Lockjaw): Tetanus bacteria enter the body through cuts, scratches or wounds in the skin. Wounds that are especially prone to infection are burns, fractures, deep wounds or wounds contaminated with soil, dust, horse manure/dung or wood splinters. The bacteria release a toxin (poison), which can cause muscle stiffness, painful muscle spasms, fits and even death. The muscle spasms can be strong enough to cause bone fractures of the spine.
  • Pertussis (Whooping cough): Pertussis is a highly infectious illness. The disease affects the airways causing severe spells of coughing that may interfere with normal breathing. The coughing is often accompanied by a “whooping” sound, hence the common name “whooping cough”. The cough may last for 1-2 months or longer. Pertussis can also cause ear infections, bronchitis which may last a long time, pneumonia, fits, brain damage and even death.
  • Hepatitis B: Hepatitis B is caused by the hepatitis B virus. It causes the liver to become inflamed and swollen. The virus is found in body fluids such as blood, semen, vaginal secretions, or saliva (spit) of infected people.

How should I take Tritanrix Hb?

The doctor will give Tritanrix HB as an injection into the thigh muscle. Your child will remain under medical supervision for 30 minutes after each injection.

The vaccine should never be given into a vein.

Your child will receive a total of three injections with an interval of at least one month between each one. Each injection is given on a separate visit. You will be informed by the doctor or nurse when you should come back for subsequent injections.

If additional injections are necessary, the doctor will tell you.

Make sure your child finishes the complete vaccination course of three injections. If not, your child may not be fully protected against the diseases.

How do I store Tritanrix Hb?

Tritanrix Hb is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Tritanrix Hb that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Tritanrix Hb down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tritanrix Hb?

Tritanrix HB should not be given in case of:

  • Your child has previously had any allergic reaction to Tritanrix HB, or any ingredient contained in this vaccine. Signs of an allergic reaction may include itchy skin rash, shortness of breath, and swelling of the face or tongue.
  • Your child has previously had an allergic reaction to any vaccine against diphtheria, tetanus, pertussis (whooping cough) or hepatitis B diseases.
  • Your child experienced problems of the nervous system within 7 days after previous vaccination with a vaccine against pertussis (whooping cough) disease.
  • Your child has a severe infection with a high temperature (over 38°C). A minor infection such as a cold should not be a problem, but talk to your doctor first.

Also, take special care with Tritanrix HB when your child have:

  • Experienced any health problems after previous administration of a vaccine, such as:
    • A high temperature (over 40°C) within 48 hours of vaccination
    • A collapse or shock-like state within 48 hours of vaccination
    • Persistent crying lasting 3 hours or more within 48 hours of vaccination
    • Seizures/fits with or without a high temperature within 3 days of vaccination
  • Suffered from an undiagnosed or progressive disease of the brain or uncontrolled epilepsy. After control of the disease, the vaccine should be administered.
  • A bleeding problem or bruises easily
  • A tendency to seizures/fits due to a fever

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Tritanrix Hb during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Tritanrix Hb.

Side effects

What side effects can occur from Tritanrix Hb?

Like all medicines, Tritanrix HB can cause side effects, although not everybody gets them.

Very common side effects are:

  • Pain or discomfort at the injection site
  • Redness or swelling at the injection site
  • Fever more than 38OC
  • Drowsiness
  • Irritability
  • Unusual crying
  • Feeding problems

Common side effects are:

  • Infection of the middle ear
  • Bronchitis
  • Sore throat
  • Discomfort when swallowing
  • Gastrointestinal symptoms such as vomiting and diarrhea

Uncommon side effects may include:

  • Pneumonia
  • Serious lung infection
  • Respiratory disorder
  • Local or widespread rashes (that may be itchy or blistering)
  • Swelling of the eyes and face
  • Difficulty in breathing or swallowing
  • A sudden drop in blood pressure
  • Loss of consciousness

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Tritanrix Hb?

Tritanrix Hb may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Tritanrix Hb?

Tritanrix Hb may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Tritanrix Hb?

Tritanrix Hb may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Tritanrix Hb.

What is the dose of Tritanrix Hb for an adult?

The dosage has not been established in adults patients.

What is the dose of Tritanrix Hb for a child?

The recommended dose (0.5 ml) of the vaccine must be administered.

Primary vaccination schedule consists of three doses within the first six months of life. Following the monovalent HB dose at birth, vaccination with the Tritanrix HB combined vaccine should start at 6 weeks of age. Three vaccine doses must be administered at intervals of at least 4 weeks.

In the case of children born of known HB carrier mothers, the immune prophylactic measures for hepatitis B should not be modified. This may require separate vaccination with HB and DTwP vaccines and also include the administration of HBIg at birth.

How is Tritanrix Hb available?

Tritanrix Hb is available in the following dosage forms and strengths:

  • Tritanrix Hb vial 0.5 ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If your child misses a scheduled injection, talk to your doctor and arrange another visit.

Hello Health Group does not provide medical advice, diagnosis or treatment.



Review Date: March 12, 2017 | Last Modified: March 12, 2017

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