Generic Name: Trimipramine Brand Name(s): Trimipramine.


What is Trimipramine used for?

Trimipramine is commonly used to treat low mood (depression).

How should I take Trimipramine?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

Take with or without food. Take with food if it causes an upset stomach.

Keep taking trimipramine as you have been told by your doctor or other health care provider, even if you feel well.

It may take a few weeks to see the full effect.

How do I store Trimipramine?

Trimipramine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Trimipramine in the bathroom or the freezer. There may be different brands of Trimipramine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Trimipramine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Trimipramine?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Trimipramine or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have had a recent heart attack.
  • You have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson’s disease like selegiline or rasagiline in the last 14 days. Taking trimipramine within 14 days of those drugs can cause very bad high blood pressure.
  • You are taking any of these drugs: Linezolid or methylene blue.

Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.

Avoid driving and doing other tasks or actions that call for you to be alert until you see how trimipramine affects you.

To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.

If you have been taking this medicine for many weeks, talk with your doctor before stopping. You may want to slowly stop trimipramine.

Talk with your doctor if you have seizures or have ever had seizures.

If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.

Avoid drinking alcohol while taking this medicine.

Talk with your doctor before you use other drugs and natural products that slow your actions.

Some people may have a higher chance of eye problems with trimipramine. Your doctor may want you to have an eye exam to see if you have a higher chance of these eye problems. Call your doctor right away if you have eye pain, change in eyesight, or swelling or redness in or around the eye.

You may get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.

Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.

If you are 65 or older, use this medicine with care. You could have more side effects.

Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using trimipramine while you are pregnant.

Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Trimipramine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Trimipramine. Trimipramine is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Trimipramine?

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • If you are planning to harm yourself or the want to harm yourself gets worse.
  • Very bad dizziness or passing out.
  • Feeling confused.
  • Not able to pass urine.
  • Very nervous and excitable.
  • Feeling very tired or weak.
  • Chest pain or pressure or a fast heartbeat.
  • Mood changes.
  • Behavioral problems.
  • Ringing in ears.
  • Trouble controlling body movements.
  • Any unexplained bruising or bleeding.
  • Yellow skin or eyes.
  • Change in sex ability.

A very bad and sometimes deadly health problem called serotonin syndrome may happen. The risk may be greater if you take this medicine with drugs for depression, migraines, or certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; very bad diarrhea, upset stomach, or throwing up; or very bad headache.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Trimipramine?

Trimipramine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Trimipramine?

Trimipramine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Trimipramine?

Trimipramine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Trimipramine.

What is the dose of Trimipramine for an adult?

Usual Adult Dose for Depression


  • Initial dose: 75 mg orally per day in divided doses
  • Maintenance dose: 50 to 150 mg orally per day
  • Maximum Dose: 200 mg orally per day

Hospitalized patients:

  • Initial dose: 100 mg orally per day in divided doses
  • Maintenance dose: 200 mg orally per day
  • Maximum Dose: 300 mg orally per day

Usual Geriatric Dose for Depression

Initial: 50 mg orally per day

Maintenance dose: 100 mg orally per day

What is the dose of Trimipramine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Trimipramine available?

Trimipramine is available in the following dosage forms and strengths:

  • Capsule

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Trimipramine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.


Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: November 22, 2017 | Last Modified: November 22, 2017

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